Epilepsy is among the most common serious neurological disorders and affects around 50 million people worldwide, 80% of which live in developing countries. Despite introduction several new Anti-Epileptic Drugs (AEDs) last two decades, one third treated patients have seizures refractory to pharmacotherapy. This highlights need develop treatments with drugs targeting alternative seizure-induction...

Epilepsy is a neurological disorder characterized by recurrent seizures, i.e. abnormal synchronous activity of neurons in the brain. The brain region responsible for the epileptic activity is called the epileptogenic region. In most cases epilepsy can be cured by using anti-epileptic drugs. However, approximately 25% of the patients cannot be cured through medication or by medical treatment, th...

Ketogenic diets are high in fat and low in carbohydrates and represent a well-established and effective treatment alternative to anti-epileptic drugs. Ketogenic diets are used for the management of a variety of difficult-to-treat or intractable seizure disorders, especially pediatric refractory epilepsy. However, it has been shown that this dietary therapy can reduce seizures in people of all a...

BACKGROUND A variety of neurological disorders have been reported in association with celiac disease (CD) including epilepsy, ataxia, neuropathy and multifocal leucoencephalopathy. The purpose of this study was to assess the prevalence of CD among epileptic patients. METHODS Our study population consisted of 108 consecutive unexplained epileptic patients from Epilepsy Clinics. Patients who we...

OBJECTIVE There are some controversial studies on effects of anti-epileptic drugs (AEDs) on serum IgG subclasses; however, the role of these medications is still unclear. The aim of this study was evaluation the effects of anti-epileptic drugs on serum concentration of IgG and its subclasses METHODS Serum IgG and IgG subclasses of 61 newly diagnosed epileptic patients were measured at the beg...

OBJECTIVES Myoclonic epilepsy (ME) syndrome is not rare in north-eastern Europe; it is also seen in various forms. Familial occurrence of ME syndrome and acute intermittent porphyria (AIP) was observed in three siblings. The following report was aimed the differentiation between co-morbidity of two different disorders or presence the epileptic seizures within the clinical picture of latent AIP....