Diabetes mellitus is believed to bring negative effects on the male reproductive system through an increase in oxidative stress. Gynura procumbens, a local herb with anti-hyperglycemic and anti-diabetic properties, has been traditionally used to treat the disease. The present study aimed to assess the anti-diabetic activity of aqueous G. procumbens and the effect of treatment on the reproductiv...

The intestinal absorption of oral-anti diabetic drugs in type-II Diabetes mellitus is altered when concomitantly administered with other drugs like, antacids, antinuclear drugs, antibiotics and others. Drug therapy becomes more complex as many individuals are on multiple drug therapy and administer many drugs during same period of time. An increasing number of drug related problems caused by dr...

Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for diabetes mellitus. The aim of present study was to demonstrate the hypoglycemic and anti-diabetic activity of the Ethanolic extract of tinospora cardifolia whole plant in alloxan induced diabetic animals with a view to explore its use for the treatment of diabetes mellitus in humans. The Eth...

Objective(s): Genistein, as a phytoestrogen found in legumes, has several biological activities in general and anti-diabetic activity particularly. In this study, we investigated the effect of genistein on proteins involved in β-cell proliferation, survival and apoptosis to further reveal its anti-diabetic potential in the ovariectomized diabetic rat. Materials and Methods: We used three-month-...

Patients with type 2 diabetes mellitus have a twofold increased risk of cardiovascular mortality compared with non-diabetic individuals. There is a growing awareness that glycemic efficacy of anti-diabetic drugs does not necessarily translate to cardiovascular safety. Over the past few years, there has been a number of trials evaluating the cardiovascular effects of anti-diabetic drugs. In this...

Aim: The present study investigates the effect of Ramipril on blood sugar level and interaction with the oral anti-diabetic drugs in alloxan induced diabetic rats. Method: Rats were divided into 10 groups (n = 6) where Group I –II were normal and Group III –X were diabetic. Ramipril at the dose of 0.9 mg/kg body weight were administered to the normal and diabetic rats. In diabetic groups, the R...

OBJECTIVE Diabetic glomerulosclerosis is a common cause of proteinuria in patients with type 2 diabetes mellitus (DM), however, primary glomerulonephritis can superimpose on it. The aim of this study is to evaluate the significance of anti-glomerular basement membrane (GBM) antibodies in type 2 DM. METHODS We choose 60 well known Saudi patients with type 2 DM diagnosed according to American D...