the rotavirus nonstructural protein 4 (nsp4), is a multi functional protein that play key role in both viral morphogenesis and cytopathic effect associated with cell death. however, the complete biological effect of nsp4 remains to be clarified. since to obtain further knowledge about this protein there is a need for recognizing antibody and there is no commercial antibody against this protein...

interferon is a protein secreted by eucaryotic cells following stimulation by viruses, bacteria, and many other immunogenes. recent medical studies indicate that interferons have effective role in the treatment of virus infections, immunodeficiency and certain types of cancer such as hairy cell leukaemia (hcl). the aim of the present study is to apply yeast strain for secreting human ifnα2b fol...

objective: dna vaccines have been widely used to develop immunity against various pathogens including parasites and viruses. the potential of dna vaccine to induce an effective immune response is related to the expression levels of the encoded protein in eukaryotic cells. therefore, optimization of plasmid dna delivery system is a major concern in protein expression in order to make an efficien...

BACKGROUND CD23 is a differentiation/activation antigen expressed by a variety of hematopoietic and epithelial cells. It can also be detected in soluble forms in biological fluids. Initially known as the low-affinity receptor for immunoglobulin E (Fc epsilonRII), CD23 displays various other physiologic ligands such as CD21, CD11b/c, CD47-vitronectin, and mannose-containing proteins. CD23 mediat...

Artificial cell-like communities participate in diverse modes of chemical interaction but exhibit minimal interfacing with their local environment. Here we develop an interactive microsystem based on the immobilization a population enzyme-active semipermeable proteinosomes within helical hydrogel filament to implement signal-induced movement. We attach large single-polynucleotide/peptide microc...

lentil wilt, caused by fusarium oxysporum f. sp. lentis is one of the main limiting factors to successful lentil cultivation. effect of four antagonistic fungi, namely: piriformospora indica, sebacina vermifera, trichoderma viride and trichoderma harzianum as well as combinations among them were evaluated against fusarium wilt of lentil. in in vitro experiments, the effect of the antagonistic f...

Abstract This review is devoted to the 100-year history of investigation peptide hormones and creation drugs on their basis, starting from insulin discovery its introduction into a medical practice in 1921. The basic groups are discussed: neurohypophyseal hormones, hypothalamic releasing incretins, insulin, adrenocorticotropic hormone (ACTH), calcitonin. first therapeutic agents based were crea...