The recent report by Bivins (1) on the successful cultivation of the wart agent on the chorioallantoic membrane (CAM) of embryonated hen's eggs and the report by Strauss, Bunting and Melnick (2) on the electron microscopy of elementary virus bodies in wart tissue prompted the undertaking of similar and extended experiments in this laboratory. Felsher (3) had ground up 3 warts in saline and had ...

INTRODUCTION Cryotherapy with liquid nitrogen is an effective, safe and convenient form of treatment for plantar warts. EMLA® cream (eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is a topical local anaesthetic agent that has proven to be effective and well tolerated in the relief of pain associated with various minor interventions in numerous clinical settings. MATERIALS AND METHODS...

UNLABELLED Study Type - Prognosis (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? In animals, anogenital distance has been shown to be related to the action of fetal androgens, and exposure to chemicals such as dioxins that exhibit antiandrogenic activity results in shorter distances in male rats. In studies conducted in children, anogenital distance has ...

ETIOLOGY — Condyloma acuminatum is caused by human papilloma virus (HPV) infection. HPV encompasses a family of highly infectious and primarily sexually transmitted double-stranded DNA viruses. The incubation period after exposure ranges from three weeks to eight months. Most infections are transient and cleared within two years [2]. Persistent infections in the setting of other clinical risk f...

We would like to thank Oguz Kutlu A for her close interest in our paper entitled “Anogenital Distance in Turkish Newborns”. In our study (1), we used caliper for the measurements as Oguz Kutlu A did in her study (2). We compared our anogenital measurements to those obtained in previous studies in the literature (including Oguz Kutlu’s study) according to the measurement method used, as shown in...

Acral melanoma is a great pretender; anything but i nfrequently, it adopts clinical faces, simulating skin conditions that make the healthcare provider diagnose it as a benign disease of the palms, soles, and ungual regions. We present a case of a hyperkeratotic acral melanoma that has been misdiagnosed and that has led to an amputation of the thumb.

Carcinoma cuniculatum is a rare low-grade well-differentiated squamous cell carcinoma, located mainly on lower limb and essentially on the plantar region (89%). It is the prerogative of the older male. Its pathogenesis remains unknown. Clinical features are suggestive of carcinoma cuniculatum, but histological confirmation often requires multiple deep biopsies namely histological examination of...

The association between the expression of HLA-DR antigens on cervical epithelium and the local immune state of activation in colposcopically obtained biopsy specimens from patients with histologically documented wart virus infection was investigated. In normal cervical epithelium no HLA-DR staining was detected. No or few IL-2R positive cells were found in the contiguous sections. HLA-DR was ex...

Beta-lactamase-negative Neisseria gonorrhoeae infections were treated with single-dose cefoperazone (0.5 or 1.0 g) or spectinomycin (2.0 g). Anogenital infections were cured in 36 (83%) of 43 volunteers given 0.5 g of cefoperazone, 61 of 61 volunteers given 1.0 g of cefoperazone, and 99 of 100 volunteers given spectinomycin. The cefoperazone geometric mean MIC for 242 isolates was 0.028 microgr...

Papillomavirus DNA has been reported recently in the vapor (smoke plume) derived from warts treated with carbon dioxide laser; this raises concerns for operator safety. We therefore have studied a group of human and bovine warts to define further the potential risk of wart therapy and to test whether a surgical mask could reduce exposure. Half of each wart was treated with carbon dioxide laser ...