Amyloid disease is rare as a complication of ankylosing spondylitis. The autopsies of Teilum and Lindahl (1954) included two such cases but no clinical details were given. A third case, in which the final histological diagnosis was also made at autopsy, was reported by Halford and Clark (1957). The aim of this paper is to report three cases of ankylosing spondylitis in which the presence of amy...

Relatively few patients develop such severe degenerative temporomandibular joint (TMJ) disease that they require total joint replacement. Current indications include those conditions involving condylar bone loss such as degenerative (osteoarthritis) or inflammatory joint disease (ankylosing spondylitis, rheumatoid, and psoriatic). Ankylosis of the temporomandibular joint (TMJ) secondary to anky...

A case of ankylosing spondylitis with aortic valve disease and hearing loss is described. A series of radiographic and audiometric investigations showed the hearing loss to be of a conductive type. It seemed most likely that the hearing loss was related to an inflammatory involvement of the ossicular joints due to the primary disease. No other case of conductive hearing loss has previously been...

A study was conducted to compare the gait pattern of 12 patients with ankylosing spondylitis with axial disease only with that of 11 healthy controls using a telemeterised electrogoniometer gait analysis system. The reproducibility of the gait variables was found to be acceptable. Angles for movement at the hip and knee were less in patients with ankylosing spondylitis, but hip/knee angle ratio...

The association between the major histocompatibility antigen HLA-B27 and ankylosing spondylitis is the strongest of all known associations between class I HLA and disease. Over 90% of patients with ankylosing spondylitis have B27,1 whereas it is found only in 7-15% of normal white subjects. In addition, B27 is associated with certain reactive inflammatory conditions following gastrointestinal o...

A 56 year old man with ankylosing spondylitis and discovertebral destruction presented with signs of spinal cord compression that was the result of the soft tissue reaction occurring at the level of the discovertebral destruction. This case emphasises the importance of early recognition, use of appropriate imaging techniques (computed tomographic myelography or magnetic resonance), and operativ...

198 It is of note that the OMERACT process has been emulated by 2 other independent groups: one in the field of chronic juvenile arthritis5, and one in ankylosing spondylitis6. The former first developed a core set followed by response criteria, closely mimicking the process of the American College of Rheumatology and OMERACT for adult rheumatoid arthritis. The latter initially formulated a cor...

Three monozygotic twin pairs, each over the age of 45 years, with ankylosing spondylitis are described. In two pairs there is discordance for this disease and in the third pair there is a marked difference in the severity of this disease. These findings provide evidence that environmental factors are necessary not only for the initial development of ankylosing spondylitis, but possibly also for...

ankylosing spondylitis (as) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. according to recent studies, erap1 is the second most common candidate gene for  as susceptibility after hla-b27. the  aim of this study was to  determine the association of erap1 gene polymorphisms with as in iranian population. the study group comprised 387 iranian as patients and 316 h...

Genes located outside the HLA region (6p21) have been considered as candidates for susceptibility to ankylosing spondylitis. We tested the hypothesis that the G22A polymorphism of the adenosine deaminase gene (ADA; 20q13.11) is associated with ankylosing spondylitis in 166 Brazilian subjects genotyped for the HLA*27 gene (47 patients and 119 controls matched for gender, age and geographic ...