AIMS To establish a simple model of conjunctival wound healing in the mouse eye. METHODS 4 week old BABL/c mouse eyes were studied over a 14 day period. Surgical procedure under general anaesthesia involved a blunt dissection of the conjunctiva performed by injection of 25 microliters of PBS via a 27 gauge needle into one eye, while the contralateral eye was used as control. Mice were assesse...

Stomatopods (mantis shrimps) possess apposition compound eyes that contain more photoreceptor types than any other animal described. This has been achieved by sub-dividing the eye into three morphologically discrete regions, a mid-band and two laterally placed hemispheres, and within the mid-band, making simple modifications to a commonly encountered crustacean photoreceptor pattern of eight ph...

PURPOSE To evaluate the retinal toxicity of intravitreal bevacizumab in an animal model. DESIGN Animal study. METHODS Bevacizumab was injected into the vitreous of one eye of each of eight Dutch-belted rabbits; the other eye served as a control. Four rabbits received a dose of 1.25 mg/0.05 ml of bevacizumab intravitreally into one eye, and the other four rabbits were injected with 2.5 mg/0....

Animal development requires that positional information act on the genome to control cell fate and cell shape. The primary determinant of animal cell shape is the cytoskeleton and thus the mechanisms by which extracellular signals influence the cytoskeleton are crucial for morphogenesis. In the developing Drosophila compound eye, localized polymerization of actin functions to constrict the apic...

doi:10.1136/inp.d1810 Natasha Mitchell graduated from University College Dublin in 1998. She worked in small animal practice in the UK and Australia before undertaking a residency at an ophthalmology referral practice in Herefordshire in 2006. She now runs her own referral veterinary ophthalmology business in Limerick, Ireland. She holds the RCVS certificate in veterinary ophthalmology and is c...

Objective- To compare the effects of topical eye-drop and subconjunctival administration of diclofenac on improvement of experimental corneal alkali wound in rabbits eyes. Design- Experimental study. Animal- fifteen rabbits. Procedures- Alkali wounds were inflicted on the central corneas of 15 rabbits which we...

purpose: to evaluate the complications of scleral perforation during strabismus surgery and the role of cryopexy, laser therapy, and conservative management in an animal model. methods: in this experimental study, 42 pigmented-eye rabbits were included. an s-24 needle attached to a 6-0 polyglactin suture was passed through the sclera and into the vitreous cavity in both eyes of the animals. one...

PURPOSE To develop a magnetic resonance (MR) imaging approach to noninvasively image quantitative Po(2) in the human vitreous. MATERIALS AND METHODS Human studies were approved by the institutional review board with informed consent obtained from all subjects and were HIPAA compliant. Animal studies were performed with animal care committee approval. An MR imaging method to measure the longit...

The size of the organs in the body is continuously regulated to match their functional capacity as required (review: Wallman and Winawer [79]). There is, however, probably no other organ so precisely controlled in size as the eye: to achieve full visual acuity, its length must be matched to the optical focal length of cornea and lens with a tolerance of about a tenth of a millimeter (equivalent...

Over the last 50 years, research into the developmental plasticity of the visual cortex has led to a growing understanding of first the causes and then of the underlying cellular mechanisms of amblyopia or 'lazy eye', the commonest childhood disorder of vision. While it is widely believed that amblyopia cannot be treated successfully after the age of about 7, recent animal studies have demonstr...