Skeletal development and invasion by tumor cells depends on proteolysis of collagen by the pericellular metalloproteinase MT1-MMP. Its hemopexin-like (HPX) domain binds to collagen substrates to facilitate their digestion. Spin labeling and paramagnetic nuclear magnetic resonance (NMR) detection have revealed how the HPX domain docks to collagen I-derived triple helix. Mutations impairing tripl...

A 30 nt RNA with a sequence designed to form an intramolecular triple helix was analyzed by one-and two-dimensional NMR spectroscopy and UV absorption measurements. NMR data show that the RNA contains seven pyrimidine-purine-pyrimidine base triples stabilized by Watson-Crick and Hoogsteen interactions. The temperature dependence of the imino proton resonances, as well as UV absorption data, ind...

A minicollagen containing the COL1 and NC1 domains of chicken collagen XII has been produced in insect cells. Significant amounts of trimers contain a triple-helical domain in which the cysteines are not involved in inter- but in intrachain bonds. In reducing conditions, providing that the triple-helix is maintained, disulfide exchange between intra- and interchain bonding is observed, suggesti...

This paper is aimed to understand the role of universities in regional innovation systems in China. It particularly examines how the Chinese practices concerning the universities' engagement with the society for promoting regional innovation systems are different from the western experiences which has been often understood within the Triple Helix framework (Etzkowitz & Leydesdorff, 1995, 1997)....

A Triple Helix (TH) of biand trilateral relations among universities, industries, and governments can be considered as an ecosystem in which uncertainty can be reduced auto-catalytically. The correlations among the distributions of relations span a vector space in which two vectors (P and Q) represent “sending” and “receiving,” respectively. These vectors can also be understood in terms of the ...

w The ‘‘lock-in’’ model by Arthur Arthur, W.B., 1988. Competing technologies. In: Dosi, G., Freeman, C., Nelson, R., Ž . x Silverberg, G., Soete, L. Eds. , Technical Change and Economic Theory. Pinter, London, pp. 590–607. can be extended to the case of two and even three sources of random variation. Thus, one can model a triple helix of university–industry– government relations. In the case of...

The strategic value of Triple Helix relations of university-government-industry (TH) in creating new knowledge infrastructure and developing the knowledge economy has been widely discussed within the existing innovation and knowledge economy literature. However current research and empirical evidence has been primarily focused on developed countries such as US, Japan and European countries. The...

This paper clarifies the causal paths from complex dynamic interactions among young entrepreneurs, social networking sites (SNSs), and smart devices to new SNS-based business model (BM) creation. The empirical data are collected through interviews with 102 CEOs in Korean SNS-related venture companies. Using these data, we employ the triple helix model and business model concepts to analyse how ...