BACKGROUND Invasive aspergillosis is a common life-threatening infection in patients with acute leukemia. The presence of building work near to hospital wards in which these patients are cared for is an important risk factor for the development of invasive aspergillosis. This study assessed the impact of voriconazole or caspofungin prophylaxis in patients undergoing induction chemotherapy for a...

BACKGROUND There is increasing evidence for the efficacy of the antifungal voriconazole, particularly in immunosuppression. We describe our experience of using voriconazole in children with CF. METHODS We performed a retrospective case note review of children with CF treated with voriconazole in a single centre over an 18 month period. RESULTS A total of 21 children aged 5 to 16 years (medi...

INTRODUCTION Invasive aspergillosis is a serious complication in immunocompromised patients. It is an opportunistic disease, which predominantly occurs in the lungs, although dissemination to virtually any organ is possible. Invasive aspergillosis in an immunocompetent patient with extension to the mediastinum has rarely been reported. Here, we present the case of a patient with no apparent imm...

We report a fatal case of invasive pulmonary aspergillosis in a severely ill neonate and review 43 additional cases of invasive aspergillosis reported from 1955 through 1996 that occurred during the first 3 months of life. Eleven of the 44 patients had primary cutaneous aspergillosis, 10 had invasive pulmonary aspergillosis, and 14 had disseminated disease. Most infections were nosocomial in or...

a 29-year-old woman with systemic lupus erythematosus (sle) presented with palpitation and neck swelling. initial sonography showed an ill-defined hypoechoic lesion in the right thyroid gland, mentioning subacute thyroiditis. the patient received conservative care for one week. however, her neck swelling worsened and she complained of dyspnea. follow up sonography showed marked enlargement of b...

chronic granulomatous disease is an infrequent primary immunodeficiency characterized by defective intracellular killing of ingested microorganisms thereby making patients highly susceptible to recurrent lite threatening bacterial and fungal infections. in this study, we review the medical course of an 8 yr old girl with ar-cgd. she suffered from recurrent dermal and deep abscesses, retractable...

BACKGROUND/AIM To describe a case of invasive orbital aspergillosis and evaluate treatments and outcomes. METHODS A case report and review of orbital aspergillosis treatment with voriconazole in the English language literature. CONCLUSION Amphotericin B with debridement is the current standard of care for orbital aspergillosis; however, its prognosis is unfavorable. When compared to amphote...

BACKGROUND Primary invasive cutaneous aspergillosis is a rare fungal infection that occurs mostly in immunocompromised patients. Newborns of very low birth weight present a high risk for this type of infection due to an immaturity of the cutaneous barrier and of the immune system. CASE PRESENTATION We describe here a case of simultaneous invasive cutaneous aspergillosis in two preterm twins. ...

Aspergillosis is a fungal disease characterized by invasive and noninvasive forms. Non-invasive aspergillosis usually affects a normal host, appearing either as an allergic reaction or a cluster of fungal hyphae. With the advent of intensive chemotherapeutic regimens, AIDS epidemic, solid organ and bone marrow transplantation, the prevalence of invasive aspergillosis has increased dramatically ...

Bronchial asthma is an inflammatory disease of the airways which may be worsened due to numerous extrinsic factors. The most common trigger is continuous exposure to allergens of which fungal agents are important factors. There is overwhelming evidence for the presence of fungal sensitization in patients with asthma. The diagnosis of fungal sensitization can be made either with skin testing wit...