Summary High-throughput sequencing of bisulfite-converted DNA is a technique used to measure DNA methylation levels. Although a considerable number of computational pipelines have been developed to analyze such data, none of them tackles all the peculiarities of the analysis together, revealing limitations that can force the user to manually perform additional steps needed for a complete proces...

Automated storage and retrieval systems (AS/RSs) are major material handling systems, which have been widely used in distribution centers and automated productions. This paper studies the characteristics of a miniload AS/RS with an open-rack structure and unidirectional-upward mobile loads within the rack. In this warehousing system, the stacker crane is used for the retrieval operations and sh...

Abstract: The study analyzes the flow over bottom racks made of longitudinal T-shaped bars. A clear water flow is considered in a laboratory flume. Free surface profiles, wetted rack lengths, and discharge coefficients are measured, changing parameters such as longitudinal slope, void ratio, and approaching flow. The present work complements existing experimental studies, considering the influe...

We conducted individual and ecologic analyses of prospectively collected data from 839 injured bicyclists who collided with motorized vehicles and presented to Bellevue Hospital, an urban Level-1 trauma center in New York City, from December 2008 to August 2014. Variables included demographics, scene information, rider behaviors, bicycle route availability, and whether the collision occurred be...

AIMS The isolation of various genes that are expressed in a region specific manner is considered useful for research in molecular pathology. In situ hybridisation (ISH) was used in a screening procedure to isolate these genes efficiently, using colon cancer as a model. METHODS Suppression subtractive hybridisation (SSH) between colon cancer tissue samples and corresponding non-cancerous tissu...

In this study, we investigated the effect of an indoor plant on task performance and on mood. Three room arrangements were used as independent variables: a room with (1) a plant, or (2) a magazine rack with magazines placed in front of the participants, or (3) a room with neither of these objects. Undergraduate students (M= 35, F= 55) performed a task of associating up to 30 words with each of ...

In this paper we examine bicycle curves from the point of view of Fourier series. We analyze necessary and sufficient conditions for a circle to admit an infinitesimal deformation as a bicycle curve with rotation number ρ and derive conditions equivalent to those obtained by Tabachnikov. We then show that whenever ρ ∈ Q is not 1 2 , that there is no such deformation. Introduction Two closed cur...

conclusions close attention to these predictors may aid officials in planning effective training programs and prevention measures. these predictors can also be used in the legislation of traffic laws and regulations and managerial plans of hospitals. patients and methods this longitudinal study reviewed 15,331 injuries in 21 hospitals in the city of tabriz from march 2012 to march 2013. the req...

GABA(A) receptors are the principal sites of fast synaptic inhibition in the brain. These receptors are hetero-pentamers that can be assembled from a number of subunit classes: alpha(1-6), beta(1-3), gamma(1-3), delta(1), epsilon, theta;, and pi, but the majority of receptor subtypes is believed, however, to be composed of alpha, beta, and gamma2 subunits. A major mechanism for modulating GABA(...