نتایج جستجو برای: ancient dna
تعداد نتایج: 542037 فیلتر نتایج به سال:
The analysis of targeted genetic loci from ancient, forensic and clinical samples is usually built upon polymerase chain reaction (PCR)-generated sequence data. However, many studies have shown that PCR amplification from poor-quality DNA templates can create sequence artefacts at significant levels. With hominin (human and other hominid) samples, the pervasive presence of highly PCR-amplifiabl...
EDITORIAL article Front. Ecol. Evol., 29 April 2021 | https://doi.org/10.3389/fevo.2021.679489
Achondroplasia (ACH) is a skeletal disorder (MIM100800) with an autosomal dominant Mendelian inheritance and complete penetrance. Here we report the screening of ancient bone samples for diagnostic ACH mutations. The diagnostic G-->A transition in the FGFR3 gene at cDNA position 1138 was detected in cloned polymerase chain reaction (PCR) products obtained from the dry mummy of the Semerchet tom...
The mitochondrial genome has been the traditional focus of most research into ancient DNA, owing to its high copy number and population-level variability. Despite this long-standing interest in mitochondrial DNA, it was only in 2001 that the first complete ancient mitogenomic sequences were obtained. As a result of various methodological developments, including the introduction of high-throughp...
Also known as... ancient DNA. The New Shorter Oxford Dictionary offers the precise explanation of ‘ancient’ as ‘belonging or pertaining to the period before the fall of the Western Roman Empire in AD 476.’ DNA can be recovered from fossils much older than 1500 years, but the inevitable time-dependent decay of the DNA structure due to oxidation and hydrolysis makes retrieval increasingly difficu...
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