RATIONALE Solitary eosinophilic granuloma (EG), the most benign, common form of Langerhans cell histiocytosis, has a self-limiting process and is associated with a good prognosis. Immobilization is recommended as the first treatment strategy for solitary EG, although the treatment protocols are still controversial. Radiotherapy and surgery are secondary treatment choices. Lesions of the upper c...

Malpositioning of the trochanteric entry point during the introduction of an intramedullary nail may cause iatrogenic fracture or malreduction. Although the optimal point of insertion in the coronal plane has been well described, positioning in the sagittal plane is poorly defined. The paired femora from 374 cadavers were placed both in the anatomical position and in internal rotation to neutra...

Methods Seven male pigs (38±2 kg) were imaged on a 3T MRI scanner (GE Excite Hdx) with a 13C birdcage coil. 13C-pyruvate (20mL of 230mM) was hyperpolarized using a Dynamic Nuclear Polarization technique (Hypersense) and injected in pigs at rest and during occlusion of the left anterior descending coronary artery. Anatomical reference images were acquired by a standard SSFP sequence. Metabolic i...

Rheumatologists have long considered OA and PsA as two completely distinct arthropathies. This review highlights how some forms of generalized OA and PsA may afflict the same entheseal-associated anatomical territories. While degeneration or inflammation may be clearly discernible at the two extremes, there may be a group of patients where differentiation is impossible. Misdiagnosis of a primar...

Listing's law (LL) states that 3D-eye positions lie in a plane, when they are described as single-axis rotations from the primary position. This implies that the degrees of freedom of eye movements are reduced from three to two. Various hypotheses exist, regarding the implementation of LL. These include facilitation of binocular vision, optimization of oculomotor control, and mechanical constra...

Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion. While in many situations these behaviors are related, the anatomical substrate of a crosstalk between the PAG and VTA remains poorly understood. Here we describe the anatomical and electrophysiological organizati...

—A realistic biomechanical model of the thumb would enhance our understanding of the functional consequences of orthopedic and neurological diseases, and of treatments. Our work has shown that a kinematic description with five orthogonal and intersecting axes of rotation cannot predict realistic thumbtip forces. An alternative kinematic description proposes five axes of rotation that need not b...

A focal stimulus triggers neural activity that spreads to cortical regions far beyond the stimulation site, creating a so-called "cortical point spread" (CPS). Animal studies found that V1 neurons possess lateral connections with neighboring neurons that prefer similar orientations and to neurons representing visuotopic regions that are constrained by their preferred orientation axis. Although ...

The development of anatomical, hydraulic and biomechanical properties in Scots pine (Pinus sylvestris L.) stems aged 7 to 59 years was followed. The hydraulic diameter and length of tracheids increased with age to a maximum at 15 and 35 years, respectively. Number of tracheids per unit of sapwood area decreased with age to a minimum of 500-600 tracheids mm(-2). Variations in specific hydraulic ...

INTRODUCTION External ears, one of the major face components, show an interesting movement during craniofacial morphogenesis in human embryo. The present study was performed to see if movement of the external ears in a human embryo could be explained by differential growth. METHODS In all, 171 samples between Carnegie stage (CS) 17 and CS 23 were selected from MR image datasets of human embry...