Recent studies have shown that the clinical outcome of anaplastic oligodendroglial tumors is variable, but also that the histological diagnosis is subject to interobserver variation. We investigated whether the assessment of 1p/19q codeletion, polysomy of chromosome 7, epidermal growth factor receptor (EGFR) gene amplification (EGFR(amp)), and loss of chromosome 10 or 10q offers additional prog...

OBJECTIVE Integrating positron emission tomographic (PET) images into the image-guided resection of high-grade gliomas (HGG) has shown that metabolic information on tumor heterogeneity and distribution are useful for planning surgery, improve tumor delineation, and provide a final target contour different from that obtained with magnetic resonance imaging (MRI) alone in about 80% of the procedu...

INTRODUCTION Anaplastic large cell lymphoma is a subset of non-Hodgkin lymphoma and an unusual disease in children. CASE PRESENTATION Herein we have reported a 7- year- old girl with a large necrotic skin ulcer on the chest caused by systemic form of anaplastic large-cell lymphoma and simultaneous active toxoplasmosis diagnosed by PCR on lymph node specimen. There were few reports showing a r...

OBJECTIVE Ovarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as estrogen and progesterone receptors (ER/PR). CASE A 29-year-old woman presented with incidental...

Anaplastic thyroid carcinoma is a rare but very aggressive tumor. Many factors that might influence the survival of patients have been suggested. The aim of our study was to determine which of the factors, known at the time of admission to the hospital, might predict survival of the patients with anaplastic thyroid carcinoma. Our aim was also to assess the relative importance of the factors and...

Kaposi sarcoma (KS), a vascular tumor caused by infection with human herpesvirus 8 (HHV8), is a systemic disease that can present with cutaneous lesions with or without visceral involvement. Very few cases of KS, most of which were associated with AIDS, have been reported in the adrenal gland. Anaplastic transformation of KS is a rare clinical presentation known as an aggressive disease with lo...

Anaplastic (undifferentiated) thyroid carcinoma is one of the most aggressive malignancies known to humans. It carries an almost uniformly fatal prognosis and, despite accounting for only 1.6% of thyroid malignancies in the United States, is responsible for more than half of all deaths attributed to thyroid cancer (1–3). Worldwide, anaplastic carcinoma constitutes 1–7% of all thyroid cancer cas...

Several recent studies have further clarified the role of chemotherapy in newly diagnosed anaplastic glioma. For newly diagnosed glioblastoma, combined daily radiotherapy with daily temozolomide followed by six cycles of adjuvant temozolomide improves overall survival. This benefit is especially observed in patients with a methylated promotor of the MGMT gene which encodes an alkyltransferase; ...

Anaplastic lymphoma kinase (ALK) is a receptor-type protein tyrosine kinase that is currently the focus of much attention in oncology. ALK is rendered oncogenic as a result of its fusion to NPM1 in anaplastic large cell lymphoma, to TPM3 or TPM4 in inflammatory myofibroblastic tumor, to EML4 in non-small cell lung carcinoma, and to VCL in renal medullary carcinoma. It is also activated as a res...

lymphoma. ALK-negative. Crit Rev Oncol Hematol. 2013;85:206–15. 4. Farace F, Bulla A, Marongiu F, Campus GV, Tanda F, Lissia A, et al. Anaplastic large cell lymphoma of the breast arising around mammary implant capsule: an Italian report. Aesthetic Plast Surg. 2013;37:567–71. 5. Fournier I, Krueger T, Wang Y, Meyer A, Ris HB, González M. Tailored thoracomyoplasty as a valid treatment option for...