objective: solenostemon monostachyus is used in traditional medicine for the treatment of various ailments such as ulcer, hypertension, pains and inflammatory diseases. evaluation of anti-inflammatory and analgesic activities of s. monostachyus aerial parts was carried out to ascertain its uses in traditional medicine. materials and methods: the aerial parts of s. monostachyus was cold extracte...

objective(s) in recent years highly selective cox-2inhibitors were withdrawn from the market because of an increased risk of cardiovascular complications. in this study we were looking for potent compounds with moderate selectivity for cox-2. so, four analogues of 4, 5-diaryl-2-(2-alkylthio-5-imidazolyl) imidazole derivatives were synthesized and their anti-inflammatory and anti-nociceptive act...

BACKGROUND the present study was designed to compare the efficacy, tolerability and safety of dexmedetomidine and fentanyl when combined with propofol during extracorporeal shock wave lithotripsy in children. METHODS fifty children aged 3-8 years, the American Society of Anesthesiologists status I and II, scheduled for elective extracorporeal shock wave lithotripsy were randomly allocated to ...

BACKGROUND Magnesium sulphate (MgSO4), NMDA receptor antagonist, is known to reduce perioperative requirement of anesthetics and analgesics. However, no studies assessed the effect of MgSO4 on onset and recovery from spinal anesthesia. A prospective, randomised, double blind study was designed to assess the effect of intravenous (IV) MgSO4 on onset and recovery from spinal anesthesia and post o...

Endoscopic submucosal dissection (ESD) is an advanced therapy for early gastric neoplasm and requires sedation with adequate analgesia. Lidocaine is a short-acting local anesthetic, and intravenous lidocaine has been shown to have analgesic efficacy in surgical settings. The aim of this study was to assess the effects of intravenous lidocaine on analgesic and sedative requirements for ESD and p...

BACKGROUND Dexmedetomidine is a highly selective α2 adrenergic agonist that has been shown to decrease the intensity of opioid-induced hyperalgesia (OIH). We aimed to investigate the antihyperalgesic effects of dexmedetomidine on high-dose remifentanil-induced hyperalgesia. METHODS Ninety American Society of Anesthesiologists physical status I-II patients undergoing laparoscopically assisted ...

Objective: To compare the outcome and complications of standard PCNL with tubeless in terms analgesia requirement, incidence infection, post-operative perinephric urinary collection hospital stay. Study Design: Randomized control trial Place Duration Study: Department Urology, Lahore General Hospital from 1st March 2018 to 30th April 2019. Methodology: Ninety six patients fulfilling inclusion c...

Children with pectus excavatum are treated surgical repair in a procedure known as minimally invasive of (MIRPE). MIRPE causes considerable postoperative pain, resulting the administration substantial dose opioids. This study aimed to identify perioperative factors that influence requirement for opioids children undergoing MIRPE. Retrospective data from who underwent were analyzed. A multimodal...

review paper, distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Global Journal of Medical Research: J Dentistry and Otolaryngology Volume 15 Issue 3 Version 1.0 Year 2015 T...

BACKGROUND In a controlled and double-blind study, the authors tested the hypothesis that preoperative insertion of intradermal needles at acupoints 2.5 cm from the spinal vertebrae (bladder meridian) provide satisfactory postoperative analgesia. METHODS The authors enrolled patients scheduled for elective upper and lower abdominal surgery. Before anesthesia, patients undergoing each type of ...