In view of non-specific toxicity of most chemotherapeutic agents against normal cells, the development of targeted chemotherapy is warranted. Efficient targeting of chemotherapeutic drugs to the cancerous area could be of great benefit for patients with advanced or metastatic tumors. Targeted cytotoxic peptide conjugates are hybrid molecules composed of a peptide carrier which binds to receptor...

background: in this study, erythromycin resistance isolates from the students with aged 12-15 yr old were studied and the mutations in the 23s rrna were identified by sequencing. methods: throat samples of 327 students with 12-15 years old from 3 schools of tehran were cultured on the selective strep­tococ­cus pyogenes medium and 23 strains were primarily selected as s. pyogenes . results: all ...

OBJECTIVE To assess the effect of starting position, target position, and various types of limb displacement on repositioning tests commonly used for clinical evaluation of rehabilitation. SETTING Controlled laboratory environment. PARTICIPANTS Sixteen healthy volunteer subjects. MAIN OUTCOME MEASURE Absolute error, ie, the absolute difference between target and replicate positions. DES...

A statistical investigation of the location of onset of intermediate and gyrating ion populations in the Earth's foreshock is presented based on Fixed Voltage Analyzer data from ISEE 1. This study reveals the existence of a spatial boundary for intermediate and gyrating ion populations that coincides with the reported ULF wave boundary. This boundary position in the Earth's foreshock depends st...

Abstract We give the proof of real analyticity accessory parameters in Liouville field theory as a function position sources case which addition to elliptic sources, parabolic are present. The method is non trivial extension it requires an intermediate step introduction regulator. treatment holds also torus. A discussion given higher genus surfaces.