in this study, the binding of amlodipine (a ca ++ channel blocker) and arsenic (metalloid) to bovine serum albumin (bsa) was studied by equilibrium dialysis(ed) method in order to have an insight into their binding chemistry to bsa. free amlodipine concentration was increased due to addition of arsenic which reduced the binding of the compounds to bsa. however, the free fraction was not increas...

The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is reevaluated considering information from new clinical trials, meta-analyses, and recent subgroup and explanatory analyses from ALLHAT, especially those regarding heart failure (HF) and the association of drug treatment with new-onset diabetes mellitus (DM) and its cardiovascular disease (CVD) consequence...

In the present work for the determination of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine a simple, rapid and precise high performance liquid chromatography procedure has been developed and validated. The separation and quantification were achieved on a Cyano C18 column using a mobile phase of filtered and degassed mixture of buffer and acetonitrile in the ratio of 830:170 with of a...