نتایج جستجو برای: amino pyrimidines
تعداد نتایج: 212341 فیلتر نتایج به سال:
Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinylquinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2-chloro-4-(2-substituted ethyl)quinazolines. Treatment of these products, without isolation, with N-methylpiperazine results in nucleophilic displ...
Various novel pyrano [2,3-d]pyrimidines 5 and furopyrano [2,3-d]pyrimidines 7 were synthesized in 80-99% yields via a multicomponent domino Knoevenagel/hetero-Diels-Alder reaction of 1,3-dimethyl barbituric acid with an aromatic aldehyde and ethyl vinyl ether/2,3-dihydrofuran in presence of 1 mol% of indium(III) chloride. The reaction also proceeds in aqueous media without using any catalyst, b...
The three possible structural isomers of 4-(pyridyl)pyrimidine were employed for the synthesis of new pyrrolo[1,2-c]pyrimidines and new indolizines, by 1,3-dipolar cycloaddition reaction of their corresponding N-ylides generated in situ from their corresponding cycloimmonium bromides. In the case of 4-(3-pyridyl)pyrimidine and 4-(4-pyridyl)pyrimidine the quaternization reactions occur as expect...
Pyrazolo[3,4-d]pyrimidines are a class of compounds with a good activity against several cancer cell lines. Despite the promising anticancer activity, these molecules showed a poor aqueous solubility. This issue could threat the future development of pyrazolo[3,4-d]pyrimidines as clinical drug candidates. With the aim of improving their solubility profile and consequently their pharmacokinetic ...
The discovery of ferrocene in 1951 sparked off a truly remarkable interdisciplinary research activity. Since then ferrocene and its derivatives have been immensely exploited for their potential applications in diverse fields such as homogeneous catalysis, organic synthesis, supramolecular chemistry, biosensors, medicinal chemistry and materials science. It is now well established that ferrocene...
Smibert, Robert M. (Virginia Polytechnic Institute, Blacksburg, Va.). Nutrition of Vibrio fetus. J. Bacteriol. 85:394-398. 1963.-A chemically defined medium has been developed for the cultivation of both catalase-positive H(2)S-negative and catalase-positive H(2)S-positive strains of Vibrio fetus. A total of 87 strains of V. fetus, representing bovine, ovine, porcine, human, and chicken isolate...
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