Major depressive disorder (MDD) is associated with cognitive impairments that may contribute to poor functional outcomes. Clinical data suggests that the multimodal antidepressant vortioxetine attenuates some cognitive impairments in MDD patients, but the mechanistic basis for these improvements is unclear. One theory suggests that vortioxetine improves cognition by suppressing γ-amino butyric ...

In vitro effects of dihydroergotoxine, dihydroergosine, dihydroergotamine, alpha-dihydroergocriptine (ergot alkaloids), diazepam, methyl-beta-Carboline-3-carboxilate (beta-CCM), flumazenil (benzodiazepines), gamma-amino butyric acid (GABA) and thiopental (barbiturate) were studied on mouse brain (cerebrum minus cerebral cortex) benzodiazepine binding sites labeled with 3H-flunitrazepam. Specifi...

Malfunctioning of synaptic vesicle in the absence of some essential regulatory proteins causes a significant decrease in the level of neurotransmitters like gamma-amino butyric acid (GABA) leading to epilepsy. In the present work, GABA receptor associated protein (GABARAP), being the major inhibitory neurotransmitter receptor from C. elegans, is investigated for its efficacy with various antiep...

A new robust, simple and economic high performance thin layer chromatographic method was developed for simultaneous estimation of L-glutamic acid and γ-amino butyric acid in brain homogenate. The high performance thin layer chromatographic separation of these amino acid was achieved using n-butanol:glacial acetic acid:water (22:3:5 v/v/v) as mobile phase and ninhydrin as a derivatising agent. Q...

The role of brain neurotransmitter transport processes in rabies virus infection of neurons was examined. The uptake and release of gamma-amino-n-butyric acid (GABA) in rabies virus-infected embryonic rat cortical neurons was assayed using tritiated ligands. A 45% reduction of [3H]GABA uptake was observed 3 days post-infection, when a maximum level of infectious particle release occurs. At this...

Changing climatic conditions across Australia’s viticulture regions is placing increasing pressure on resources such as water and energy for irrigation. Therefore, there a pressing need to identify superior drought tolerant grapevine clones by exploring the extensive genetic diversity of early European in old vineyards. Previously, field trial, we identified drought-tolerant (DT) dry-farmed Cab...

The performance of amino acids and carboxylic acids of biological importance on the corrosion of mild steel and copper in sodium chloridesolutionswas investigated. Manyofthe amino acidsare inhibitive. Aspartic acid, cysteine, cystine, threonine and histidine enhance the corrosion of mild steel. For copper, however, all t he compounds except 4-amino n-butyric acid and hippuric acid, promote corr...

Malfunctioning of synaptic vesicle in the absence of some essential regulatory proteins causes a significant decrease in the level of neurotransmitters like gamma-amino butyric acid (GABA) leading to epilepsy. In the present work, GABA receptor associated protein (GABARAP), being the major inhibitory neurotransmitter receptor from C. elegans, is investigated for its efficacy with various antiep...