A rapid and simple procedure was devised for the synthesis of multifunctionalized cyclic β-amino esters and γ-amino alcohols via the 1,3-dipolar cycloaddition of nitrile oxides to β-aminocyclopentenecarboxylates. The opening of the isoxazoline reductive ring to the corresponding highly functionalized 2-aminocyclopentanecarboxylates occurred stereoselectively with good yields.

Visible-light-mediated photoredox-catalyzed aldimine-aniline and aldehyde-aniline couplings have been realized. The reductive single electron transfer (SET) umpolung of various carbonyl derivatives enabled the generation of intermediary ketyl and α-amino radical anions, which were utilized for the synthesis of unsymmetrically substituted 1,2-diamines and amino alcohols.

12 Higher alcohols and acetate esters are important flavour and aroma components in the food 13 industry. In alcoholic beverages these compounds are produced by yeast during fermentation. 14 Although S. cerevisiae is one of the most extensively used species, other species of the 15 Saccharomyces genus have become common in fermentation processes. This study analyses 16 and compares the producti...

Contribution of yeasts to the sensory attributes of fermented foods and beverages goes far beyond sugar consumption and ethanol and carbon dioxide production. It includes some major by-products of fermentation, like glycerol or acetic acid, and hundreds of aroma-active compounds, including higher alcohols, esters, aldehydes, organic acids, volatile fatty acids or carbonyl compounds, as main con...

Conducted experiments and collected data show that use of catalytic systems contain individual amino acids industrial catalyst – solution cobalt naphtenate with cyclohexanone have certain influence on the process liquid-phase homogeneous oxidation cyclohexane. The results spectral studies binary based NC using additives different nature (alcohols nitrogen-containing modifiers) allow us to propo...

Two darts in the middle! This work reports double addition of propargylzinc reagents to nitriles (acylcyanohydrins and cyanocarbonates). methodology provides a straightforward access dipropargylic α,α-disubstituted hydroxyamides or N-Boc-protected amino alcohols which can be converted into functionalized pyridine derivatives after cobalt-catalyzed [2+2+2] cycloaddition reactions involving nitri...

Ligand-gated ion channels are a target for inhaled anesthetics and alcohols in the central nervous system. The inhibitory strychnine-sensitive glycine and gamma-aminobutyric acid type A receptors are positively modulated by anesthetics and alcohols, and site-directed mutagenesis techniques have identified amino acid residues important for the action of volatile anesthetics and alcohols in these...

Alcohols in the homologous series of n-alcohols increase in central nervous system depressant potency with increasing chain length until a "cutoff" is reached, after which further increases in molecular size no longer increase alcohol potency. A similar phenomenon has been observed in the regulation of ligand-gated ion channels by alcohols. Different ligand-gated ion channels exhibit radically ...