Background: Given the important role of amino acids in regulating many metabolic pathways of the body and considering the scarcity of markers for the diagnosis of inflammatory bowel disease (IBD) and its differentiation, we aimed to investigate the status of serum amino acids chromatography in children with IBD. Materials and Methods This case-control study was conducted among children with pri...

Citation: Parthasarathy A, Cross PJ, Dobson RCJ, Adams LE, Savka MA and Hudson AO (2018) A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals. Front. Mol. Biosci. 5:29. doi: 10.3389/fmolb.2018.00029 A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and A...

Early studies of amino acid transport across the ovine placenta suggested that amino acids taken up by the placenta from the maternal circulation are delivered to the fetus with no major loss (placental amino acid utilization) or addition (placental amino acid production) (1). Recent data indicate that for some amino acids, this suggestion is not valid, and that amino acid metabolism is an impo...

Free amino acids in the tissue of the palatine tonsil and the adenoid were analyzed using a JEOL 6-AS Type Auto-Analyzer, and comparative examination was made on 26 kinds of amino acids discovered. Of these, 23 amino acids showed significantly high values in the palatine tonsil, but hydroxyproline and tryptophan showed somewhat higher values in the adenoid. These results suggest that the metabo...

Nineteen amino acids were determined in the plasma of young and older individuals by the chromatographic procedure of Moore, Spackman, and Stein (7,8). Of the essential amino acids, valine, methionine, isoleucine, leucine, phenylalanine, and lysine were found to be lower in older subjects. In all, 11 of the 19 amino acids studied showed lower values in these individuals, indicating some differe...

Aromatic amino acids function as building blocks of proteins and as precursors for secondary metabolism. To obtain plants that accumulate tryptophan (Trp) and phenylalanine (Phe), we modified the biosynthetic pathways for these amino acids in rice and dicot species. By introducing a gene encoding a feedback-insensitive anthranilate synthase (AS) alpha subunit, we successfully obtained transgeni...

A pilot study was performed to examine the potential of stable isotope techniques for monitoring the impact of a harmful substance on the cellular nitrogen metabolism in the ciliate species Tetrahymena pyriformis. After identical cultivation periods of control cells and toluene-exposed cells in a defined culture medium enriched with [guanidino-15N2]l-arginine, a number of nitrogen-containing po...

One important advantage of animal models is that they permit invasive approaches and can be especially valuable when evaluating tissue and specific features of metabolism in situ. The focus of this presentation is current models, which are providing insights into the pivotal importance of the gastrointestinal tract in amino acid metabolism. Intestinal amino acid metabolism is conceptually and t...