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alzheimer's disease (ad) is the most common form of neurodegenerative disorders. memory loss in an alert person and impairment in the function of language, attention, perception, judgment or problem solving can occur in patients with ad. however, there are some medications in order to delay the debilitating aspects of the disease; but unfortunately, scientists could not found approaches to...

In this study, we develop a novel nonlinear metric learning method to improve biomarker identification for Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI). Formulated under a constrained optimization framework, the proposed method learns a smooth nonlinear feature space transformation that makes the mapped data more linearly separable for SVMs. The thin-plate spline (TPS) is chosen...