Alu repeats in K562 cells are unusually hypomethylated and far more actively transcribed than those in other human cell lines and somatic tissues. Also, the level of Alu RNA in K562 cells is relatively insensitive to cell stresses, namely heat shock, adenovirus infection and treatment with cycloheximide, which increase the abundance of Alu RNA in HeLa and 293 cells. Recent advances in understan...

This paper describes the architecture, design & implementation of 2 bit ternary ALU (T-ALU) slice. The proposed ALU is designed for two-bit operation & can be used for n bit operations by cascading n/2 ALU slices. This ALU is implemented using C-MOS ternary logic gates (T-Gates) for ternary arithmetic & logic circuits. Ternary gates are implemented using enhancement / depletion MOSFET technolog...

Arithmetic Logic Unit (ALU) is a heart of microprocessor and microcontroller units that are playing main role in digital computers. By optimizing the ALU circuit in microprocessor and microcontroller highly power efficient digital system can be achieved. The use of low power and high performance sub-blocks like adder and multiplier can reduce the total power dissipation of ALU. So in this paper...

Current out-of-order architectures have the critical path in the memory structure. Since the memory access delay mainly consists of wire delays, the feature size reduction will make little contribution on the critical path reduction. Therefore, the performance of the out-of-order architecture will not improve in spite of an expected advance in future technologies. To solve this problem, we pres...

The highly repetitive Alu retroelements are regarded as methylation centres in the genome. Methylation in the gene promoters could be spreading from them. Promoter methylation of MLH1 is frequently detected in cancers, but the underlying mechanism is unclear. The aim of this study is to understand whether the methylation in the Alu elements is associated with promoter methylation in the MLH1 ge...

Indel polymorphisms are becoming increasingly useful markers for population genetic studies. These are stable mutational events that are unlikely to undergo reverse or convergent mutations, making them useful as markers for distinguishing chromosomal lineages identical by descent and for using in population diversity studies. There has been a great deal of interest to use retrotransposones like...

To study the effect of potential human immunodeficiency virus type 1 (HIV-1) integrase inhibitors during virus replication in cell culture, we used a modified nested Alu-PCR assay to quantify integrated HIV DNA in combination with the quantitative analysis of extrachromosomal HIV DNA. The two diketo acid integrase inhibitors (L-708,906 and L-731,988) blocked the accumulation of integrated HIV-1...

The mammalian signal recognition particle (SRP) catalytically promotes cotranslational translocation of signal sequence containing proteins across the endoplasmic reticulum membrane. While the S-domain of SRP binds the N-terminal signal sequence on the nascent polypeptide, the Alu domain of SRP temporarily interferes with the ribosomal elongation cycle until the translocation pore in the membra...

The first draft of the human genome has revealed enormous variability in the global distribution of Alu repeat elements. There are regions such as the four homeobox gene clusters, which are nearly devoid of these repeats that contrast with repeat dense regions in other transcriptionally active regions of the genome. Our analysis of the completely sequenced chromosomes 21 and 22 revealed a strik...