The Ma&tan alnijite contains a rich and varied megacryst suite of unprecedented compositional range. We have undertaken trace element and isotope modeling in order to formulate a petrogenetic scheme which links the host alniiite to its entrained megacrysts. This requires that a proto-alntiite magma is the product of zone refining initiated by diapiric upwelling (where the initial melt passes th...

1. On incubating cerebral-cortex slices at 37 degrees in an oxygenated medium marked changes resulted in the subcellular distribution of proteins and phosphoproteins in the tissue. The protein content of the nuclear fraction more than doubled, whereas the yields of microsomal and supernatant proteins were both markedly decreased. The amount of phosphoprotein/mg. of protein decreased in the micr...

Stable isotope analysis is recognized as a powerful tool for monitoring, assessing, and validating in-situ bioremediation processes. In this study, kinetic carbon isotope fractionation factors (epsilon) associated with the aerobic biodegradation of vinyl chloride (VC), cis-1,2-dichloroethylene (cDCE), and trichloroethylene (TCE) were examined. Of the three solvents, the largest fractionation ef...

Fractionation of cells into their subcellular components has long been a central approach in cell biology. Subcellular fractionation techniques have been used widely to study structure and function of organelles and subcellular compartments, as well as to examine the location, processing, and trafficking of molecular components. The object of most subcellular fractionation procedures is to obta...

The fractionation of lipid mixtures by classical methods based on their differential solubilities in organic solvents is an elaborate and lengthy procedure, frequently yielding products of doubtful purity. For this reason alternative methods of purification were sought. Attempts to apply adsorption chromatography were not encouraging in our hands, as the separation was poor, and invariably abou...

An increase in the cyclic AMP of nerve terminals has been proposed as intermediary in neurotransmitter release and synthesis (Wooten et al., 1973; Roth et al., 1975). However, de Belleroche et al. (1 974) were unable to increase the cyclic AMP content of synaptosome preparations after their isolation from rat neocortex, using as stimulating agents electrical pulses, noradrenaline or elevated K+...

A cellular protein of 36,000 daltons becomes phosphorylated at tyrosine in chicken embryo fibroblasts transformed with avian sarcoma viruses. We have used cellular fractionation and immunofluorescence to locate the 36-kdalton protein in virus-transformed and uninfected chicken fibroblasts. The 36-kdalton protein in transformed cells fractionated mainly with high-speed particulate material, and ...

AIMS ATP-sensitive potassium (K(ATP)) channels in the heart are critical regulators of cellular excitability and action potentials during ischaemia. However, little is known about subcellular localization of these channels and their regulation. The present study was designed to explore the potential role of caveolae in the regulation of K(ATP) channels in cardiac ventricular myocytes. METHODS...

Introduction/Background Despite treatment intensification for patients with head and neck squamous cell carcinoma (HNSCC), including altered radiation fractionation and the addition of chemotherapy to radiation, physicians and patients still face the challenge of recurrent or second tumors arising within or in close proximity to previously irradiated tissues. At 5 years after therapy, locoregio...

BACKGROUND & OBJECTIVE Radiotherapy is an important treatment for nasopharyngeal carcinoma (NPC). Timing of radiotherapy has attracted more attention nowadays. This study was to assess the efficacy of accelerated fractionation (six fractions per week) versus conventional fractionation (five fractions per week) for NPC, thus to improve treatment efficacy without increasing complications. METHO...