glycosaminoglycan (gag) has a pivot role in renal function and homeostasis. analysis of gag amount generally serves to determine gag alteration due to diabetes mellitus. critical electrolyte concentration (cec) staining can be an efficacy method to study gag amount changes. based on an experimental study, 20 male rats were randomly divided equally into two experimental and control groups. diabe...

Healing of skin wound is a multi-factorial and complex process. Proper treatment of diabetic wounds is still a major clinical challenge. Although diabetes mellitus can occur in ruminants, healing of wounds in diabetic ruminants has not yet been investigated. The aim of this study was to evaluate healing of ovine excisional diabetic wound model. Eight 4-month-old Iranian Makoui wethers were equa...

BACKGROUND Medicinal plants offer cheaper and safer treatment options to current diabetic drugs. The present study evaluated the effect of aqueous root bark extract of Zanthoxylum chalybeum on oral glucose tolerance and pancreas histopathology in alloxanized rats. METHOD Diabetes was induced in rats by administration of alloxan monohydrate. Root extract of Z. chalybeum was administered to rat...

The objective of the study was to evaluate for antidepressant like activity of a methanolic extract of B. juncea leaves (BJ 100, 200, and 400 mg/kg/day, po), and Imipramine (15 mg/kg/day, po) in alloxan monohydrate (120 mg/kg, ip) induced diabetic and nondiabetic rodents, using behavioural despair, learned helplessness, and tail suspension tests for antidepressants and locomotor activity test f...

To investigate the influence of the pineal gland through melatonin secretion on the physiological and morphological parameters of pancreatic islets, we studied the plasma biochemistry and morphological and morphometric characteristics of the endocrine pancreas of male Wistar rats. The animals were distributed into five groups of ten rats each: NC - normal control group; NS -- sham-operated grou...

Objective(s): Panax ginseng (PG) widely used for its various pharmacological activities, including effects on diabetes and its complications. This study aims to investigate the effect of PG on mortality-related hypomagnesemia, hyperlactatemia, metabolic acidosis, and other diabetes-induced abnormalities. Materials and Methods: Type 1 dia...

Abstract Objectives The purposes of this study were to produce novel formulations Doeeneh using three probiotic strains and different inulin ratios investigate the survival probiotics. Likewise, effect on biological properties non-diabetic diabetic rats was also evaluated. Materials Methods composed milk wheat bulgur enriched with proportions fermented by Bifidobacterium animalis subsp. lactis ...

Cytochrome c was reduced when superoxide was generated from xanthine oxidase in the presence of alloxan, and by the reaction of alloxan and with reduced glutathione. In each case, most of the reduction was inhibited by superoxide dismutase, but considerably more enzyme was required than with superoxide alone. This indicates that the superoxide dismutase-inhibitible cytochrome c reduction was ma...

Whether alloxan or diabetes is responsible for the lowered concentration of amino acids in aqueous humor and lenses of rabbits made diabetic by this drug was investigated. The rate of accumulation of <C-cycloleucine (l-amino cyclopentane carboxylic acid) in both posterior aqueous and lens was depressed to essentially the same degree in rabbits made diabetic by pancreatectomy or by alloxan. The ...