The observables of the GOCE three-axis gradiometer are taken in time, along the orbit and, in the timewise proposal, filtered to stay in the measurement bandwidth, i.e. in the frequency interval between 0.005 and 0.1 Hz. As a consequence, the resulting “observable” is a convolution of the original data stream with a time-wise weighting kernel. In other words, we cannot assume that the observati...

2 Methods 5 2.1 Multiple hypothesis testing framework . . . . . . . . . . . . . 5 2.2 Test statistics null distribution . . . . . . . . . . . . . . . . . 11 2.3 Single-step procedures for control of general Type I error rates θ(FVn) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.4 Step-down procedures for control of the family-wise error rate 16 2.5 Augmentation multiple tes...

We consider a clinical trial with a primary and a secondary endpoint where the secondary endpoint is tested only if the primary endpoint is significant. The trial uses a group sequential procedure with two stages. The familywise error rate (FWER) of falsely concluding significance on either endpoint is to be controlled at a nominal level α. The type I error rate for the primary endpoint is cont...