Carol S. Newlon essential for DNA replication and is required for the assembly and maintenance of the pre-RC, are excellent Department of Microbiology and Molecular Genetics candidates for components of the pre-RC. Other candidates include products of genes known to be required UMDNJ–New Jersey Medical School Newark, New Jersey 07103 for the initiation of DNA replication, including the mini-chr...

What does partnership mean? Together. On the same side. Working as one. At least, that’s what it means to me, so the tone of some of the recent debate on patient empowerment has surprised me. Many articles in the medical press are telling doctors to get out of the driving seat—saying that we oppress patients, who need “emancipation.” Much of medicine is still grounded in paternalism; this is tr...

Trust management involves the identification and analysis of trust relations. However, adequately managing trust requires all the relevant aspects of trust to be addressed. Moreover, which aspects to address depend on the perspective of the trust management. In this position paper we relate the notion of trust to the notions of uncertainty, subjectivity and risk, and we explain how these aspect...

Computer displays are being designed for increasingly larger industrial systems. As the application domain scales up, maintaining integration across different kinds of views becomes more challenging. This paper presents the results of a study of three different approaches to integration based on the spatial and temporal proximity of related information objects. The domain used for evaluation wa...

In order to be more flexible in publishing information and improve accessibility of information for end-users, Oslo Municipality has funded the SUBLIMA project [25]. Within this project a stack of open source Semantic Web and Content Management System (CMS) components is used in order to deliver a flexible solution for publication of meta-data from libraries. Queries from a specific front-end a...

Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical signals into biochemical responses, has focused on identification of critical mechanosensitive molecules and cellular components. Stretch-activated ion channels, caveolae, integrins, cadherins, growth factor receptors, myosin motors, cytoskeletal filaments, nuclei, extracellular matrix, and numerous other ...

Bacterial biofilms are integrated, multi-species communities of cells that adhere to almost any surface and are fundamental to the ecology and biology of bacteria. Not only do biofilms contribute to human health and disease, they also play important roles in the context of energy and the environment. The formation of biofilms requires interactions between bacteria and the surfaces they colonize...

Polar auxin transport and the action of the actin cytoskeleton are tightly interconnected, which is documented by the finding that auxin transporters reach their final destination by active movement of secretory vesicles along F-actin tracks. Moreover, auxin transporter polarity and flexibility is thought to depend on transporter cycling that requires endocytosis and exocytosis of vesicles. In ...