Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...

In medicinal chemistry nitrogen containing heterocycles are the most important compounds which show various biological activities. The cinnoline are nitrogenous derivatives and found to elicit many pharmacological actions like anti-hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity. We planned to synthesis new series of ...

From few decades, fused heterocyclic chemistry has occupied a prominent place in Medicinal Chemistry. Moreover, fused imidazole systems have attracted the researcher’s interest due to their natural occurrence and significant medicinal applications [1-3]. Additionally, the benzimidazole derivatives are the bioisosters of natural nucleotides, which can interact easily with the macromolecules (pro...

I. Phosphorylated derivatives of histidine were synthesized and studied in order to provide a better understanding of the chemistry of phosphohistidine-containing proteins, i-Phosphohistidine, 1,3-diphosphohistidine, a, 1,3-triphosphohistidine, and phosphorylated derivatives of ~-N-acetylhistidine were prepared by reactions with POC13 or phosphoramidate. The compounds were purified by ion-excha...

A series of azole derivatives (5a-d, 6a-d and 7a-d) have been synthesized from (2,4,5-triphenyl-imidazole-1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized azole derivatives have been investigated for their antiinflammatory, antibacterial and antifung...

The syntheses of novel hydrazono acyclic nucleosides similar to miconazole scaffolds are described. In this series of acyclic nucleosides, pyrimidine as well as purine and other azole derivatives replaced the imidazole function in miconazole and the ether group was replaced with a hydrazone moiety using phenylhydrazine. To interpret the dominant formation of (E)-hydrazone derivatives rather tha...