Pemetrexed (PEM) is used for treatment of non-small cell lung cancer. However, PEM has disadvantages like fast elimination, low bioavailability, poor tumor selectivity, and penetration. Thus, there a need using pemetrexed delivery system to increase the anticancer effect drug in cancer cells minimize its side effects. The purpose this study development alginate/chitosan nanoparticles (ACNP) tha...

Sodium-alginate (SA) based nanofluids represent a new generation of fluids with improved performances in terms heat transfer. This work examines the influence nanoparticle shape on non–Newtonian viscoplastic Cu–nanofluid pertaining to this category. In particular, stretching/shrinking sheet subjected transverse magnetic field is considered. The proposed consists four different nanoparticles hav...

Alginate denotes a group of industrially important 1-4-linked biopolymers composed of the C-5-epimers β-D-mannuronic acid (M) and α-L-guluronic acid (G). The polysaccharide is manufactured from brown algae where it constitutes the main structural cell wall polymer. The physical properties of a given alginate molecule, e.g., gel-strength, water-binding capacity, viscosity and biocompatibility, a...

Background: Our goal was to prepare and evaluate topical ophthalmic formulations containing optimized celecoxib-loaded bioadhesive cationic chitosan or anionic alginate nanoparticles for sustained release of celecoxib. Methods: Nanoparticles were prepared using a spontaneous emulsification solvent diffusion method. Different concentrations of polymers, emulsifier and stabilizers were used to op...