Therapy with antilymphocyte globulin (ALG) has been shown to be effective in restoring hematopoiesis to some patients with aplastic anemia. It would be useful to have a method for predicting those likely to be responders versus nonresponders. The mode of immunostimulatory action of ALG is of interest in addition to its immunosuppressive action. We examined in vitro the distribution of the proli...

ALG-2, a prototypic member of the penta-EF-hand protein family, interacts with Alix at its C-terminal Pro-rich region containing four tandem PXY repeats. Human phospholipid scramblase 3 (PLSCR3) has a similar sequence (ABS-1) in its N-terminal region. In the present study, we found that ALG-2 interacts with PLSCR3 expressed in HEK293 cells in a Ca(2+)-dependent manner by co-immunoprecipitation,...

Clinical preparations of horse antilymphocyteglobulin (ALG) were found to inhibit human bone marrow granulocyte colony growth. This effect was enhanced by complement and was dose dependent, being almost complete at ALG concentrations of 100 microgram/ml. Inhibition was a property of ALG but not of normal horse globulin. However, short incubation of ALG with bone marrow cells occasionally stimul...

The deoiled residue from the production of heterotrophic microalgae can be combined with soyhulls to form a novel feedstuff called algae meal (ALG). To determine the effects of replacing corn in a finishing diet with ALG on growth, mineral status, carcass characteristics, and longissimus thoracis fatty acid profile, crossbred steers (168) were blocked by BW (432 ± 30.8 kg) into pens of 6 steers...

Core-shell microcapsules with combined features of hydrophilicity and hydrophobicity have become much popular. However, the assembly biocompatible edible materials in hydrophilic-hydrophobic core-shell is not easy. In this work, based on electrostatic interactions, we prepared controllable calcium alginate (ALG)-zein particles different shapes sizes using hydrophilic ALG hydrophobic zein by a t...

ALG-2 (apoptosis-linked gene 2) is a Ca2+-binding protein that belongs to the PEF (penta-EF-hand) protein family. Alix (ALG-2-interacting protein X)/AIP1 (ALG-2-interacting protein 1), one of its binding partners, interacts with TSG101 and CHMP4 (charged multivesicular body protein 4), which are components of ESCRT-I (endosomal sorting complex required for transport I) and ESCRT-III respectivel...

ALG-2 was originally discovered as a pro-apoptotic protein in a genetic screen. Due to its ability to bind calcium with high affinity it was postulated to provide a link between the known effect of calcium in programmed cell death and the molecular death execution machinery. This review article discusses the current knowledge on the structure and potential function of this protein. Several puta...

Sodium alginate (Na-Alg) is water-soluble, neutral, and linear polysaccharide. It the derivative of alginic acid which comprises 1,4-?-d-mannuronic (M) ?-l-guluronic (G) acids has chemical formula (NaC6H7O6). shows non-toxic, biocompatible, biodegradable, non-immunogenic properties. had been used for various biomedical applications, among most promising are drug delivery, gene wound dressing, h...

Antithymocyte and antilymphocyte globulins (ALG) are currently used as immunosuppressive agents in organ transplantation and for the treatment of acute graft-versus-host disease and aplastic anemia. Since any type of immunosuppressive treatment is known to carry the risk of developing B-cell lymphoproliferative disorders, we investigated the in vitro effect of ALG on human B-cell activation and...

Antilymphocyte and antithymocyte globulins (ALG) are currently used as immunosuppressive agents in clinical transplantation and for the treatment of severe aplastic anemia. ALG contain a mixture of antibodies that recognize T- and B-cell-specific antigens but mostly nonlineage-specific molecules. We reported previously that ALG could inhibit the proliferation of activated B cells and B cell lin...