نتایج جستجو برای: aldh1
تعداد نتایج: 474 فیلتر نتایج به سال:
Current dogma favors elimination of therapy-resistant cancer stem cells for chemoprevention of breast cancer. We showed recently that mammary cancer development in a transgenic mouse model (mouse mammary tumor virus-neu; MMTV-neu) was inhibited significantly upon treatment with withaferin A (WA), a steroidal lactone derived from a medicinal plant. Herein, we demonstrate that the mammary cancer ...
Nowadays, umbilical cordand adipose-derived stem cells Background: (UCSCs and ASCs) are the most common sources of mesenchymal stem cells (MSCs). As part of the tumor microenvironment, MSCs are known to communicate with cancer cells via their secretomes. Increased activity of aldehyde dehydrogenase-1 (ALDH1) has been widely used as a common intrinsic stemness marker in normal and cancer stem ce...
Background: Copanlisib, a pan-PI3K inhibitor with stronger activity against the alpha and delta isoforms, is Food Drug Administration (FDA) approved for treatment of patients relapsed or refractory follicular lymphoma, it has shown clinical in other indolent lymphomas including marginal zone lymphoma (MZL). Preclinical studies have demonstrated strong synergism copanlisib BCL2 venetoclax differ...
MiR-208a stimulates cardiomyocyte hypertrophy, fibrosis and β-MHC (β-myosin heavy chain) expression, being involved in cardiovascular diseases. Although miR-208a is known to play a role in cardiovascular diseases, its role in cancer and cancer stem cells (CSCs) remains uncertain. We identified an inverse relationship between miR-208a and let-7a in breast cancer specimens, and found that SOX2, β...
BACKGROUND:Canine mammary gland cancers are the most prevalent malignancies in dogs. There are different challenges regarding management of these cancers in dogs and human, one hypothesis is related to small cellular subset of tumor mass called cancer stem cell. These cells are therapy resistant and cause metastasis and relapse even after primary successful treatment. The well-identified phenot...
Background/Aim: SLC20A1 has been identified as a prognostic marker in ER+ breast cancer. However, the role of expression cancer subtypes other than types remains unclear. Materials and Methods: Genomics datasets were downloaded analyzed, effect knockdown using targeted siRNA on cell viability tumor-sphere formation was assessed. Results: SLC20A1high patients with ER+, claudin-low or ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید