AIM To investigate the effects of students' usual levels of alcohol consumption on aspects of mood and anxiety the following morning. METHODS Students were recruited who consumed their usual quantity of any type of alcoholic beverage in their chosen company and then completed assessments of the effects the following day. The timing of drinking was restricted to the period between 22:00 and 02...

BACKGROUND Alcohol or drug use and associated hangover may reduce workplace safety and productivity and also cause sickness absence. The aims of this study were to examine (i) the use of alcohol and drugs, and (ii) reduced efficiency at work and absence due to such use among employees. METHODS Forty-four companies were invited; half of them agreed to participate. Employees filled in a questio...

AIM This emergency department (ED) study compared the value of plasma ethyl glucuronide (EtG) testing with the information about alcohol consumption obtained using the standard alcohol biomarkers gamma-glutamyltransferase (GGT) and carbohydrate-deficient transferring (CDT) and the AUDIT questionnaire. METHODS Minimally injured and clinically non-intoxicated male patients (n = 81) admitted to ...

Heavy alcohol use and its associated negative consequences continue to be an important health issue among adolescents. Of particular concern are risky drinking practices such as playing drinking games. Although retrospective accounts indicate that drinking game participation is common among high school students, it has yet to be assessed in current high school students. Utilizing data from high...

BACKGROUND A significant proportion of adolescents who attend celebratory events often engage in substantial alcohol and other drug use. We examined patterns, influences and impacts of drug consumption at an end of schooling life celebration. METHODS Seventeen- to 18-year-old Australians who intended to attend (n = 541) and who attended the celebration (n = 405), respectively, completed pre- ...

The consequences of drinking six pints of beer (3.31) over three hours were investigated in six healthy men. The expected rise in plasma osmolality, fall in plasma vasopressin concentration, and increase in free water clearance occurred; these variables had returned to normal by nine hours. There was a small but significant fall in plasma concentrations of urea and creatinine accompanied by a r...

The effects of a single 384 mg oral dose of chlormethiazole were compared with those of 20 mg of temazepam and placebo in healthy old and young women (mean ages 72.9 and 24.7 years respectively). Both drugs were effective hypnotics and had no detectable pharmacological action the next morning. Even four hours after administration performance of a simple psychomotor test was not impaired and swa...

The currently accepted explanation of the short action of barbiturate anesthetics is that the redistribution of drug within the body compartments and also some degree of metabolism being involved. It is, however manifestly evident that the barbiturates anesthetic are not rapidly metabolized. Thus it was assumed that molecular modifications could provide barbiturates which undergo rapid metaboli...