the antitumor activity of ethanol extract of prosopis glandulosa torr. (epg) was evaluated against ehrlich ascites carcinoma (eac) tumor model in swiss albino mice on dose dependent manner. the activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. oral administration of epg at the dose of 100, 200 and 400 mg/kg, significantl...

The methanolic extracts of Indigofera aspalathoides (MEIA) and Wedelia calendulaceae (MEWC) were evaluated for their anticancer activity against Ehrlich Ascites Carcinoma (EAC) in Swiss albino mice. On day 1, the extract of Indigofera aspalathoides at a dose of 250 and 500 mg/kg body weight and the extract of Wedelia calendulaceae at a dose of 250 and 500 mg/kg body weight were administered ora...

Resveratrol is a natural polyphenol present in the Japanese knotweed. It exhibits variety of chemopreventive and anti-proliferative effects against different cancer cell lines. During skin carcinogenesis, radical scavenging activity gets altered which are important to prevent deleterious effect free radicals. The study targeted elucidate anti-cancer potential resveratrol 7, 12-dimethylbenz[a]an...

Melatonin, as an endogenous hormone, is associated with the moderation of circadian rhythm. Besides controlling sleep-wake cycle, many physiological functions melatonin have been identified, such antioxidant, immune modulating, and anti-inflammatory. The current study was designed to estimate effect different doses on gene expression (TNF) in serum mitotic index (MI) bone marrow stem cells cyto...

In both scotopic and photopic conditions, the rotation of a grating was found to elicit head movements in mice. The highest spatial frequency eliciting this optomotor response provided an estimate of visual acuity. In male C57BL/6J mice, visual acuity increased from 0.26cpd in scotopic conditions to 0.52cpd in photopic conditions whereas it was 0.52 cpd in both sets of conditions in 129/SvPas m...

Many drugs have been found to induce oxidative stress. Oxidative stress is responsible for a large number of diseases. Chloroquine one the drugs, which can stress, when it given at higher dose. Purpose: To find effect chloroquine as inducer on albino mice. Study Design: Randomized clinical trial. Methodology: Sixty male mice were taken into this randomized controlled study. Those divided two gr...

The cytokines IFN-?, interleukin IL-1?, and TNF-? each up regulate the expression of major histocompatibility complex (MHC) are therefore considered as inflammatory markers. present study aimed to measure serum levels in mice after induction diabetes with streptozotocin correlate their lipid glycaemic profiles. included 40 Swiss Albino (20 males 20 females), half male female groups were made di...

The protective effects of Mentha piperita (Linn) extract against radiation induced hematopoietic damage in bone marrow of Swiss albino mice have been studied. Mice were given either double distilled water or leaf extract of M. piperita orally (1 g/kg b.wt./day) once a day for three consecutive days, and after 30 min of treatments on the third day were exposed to 8 Gy gamma radiation. Mice were ...

Background: Natural products, those extracted from invertebrate animals have medical importance as therapeutic agents especially for cancer treatment. Aim of the Work: The current study was conducted to evaluate antitumor effect hemolymph desert snail, Helix desertorum (HD-H) on tumor Ehrlich ascetic carcinoma cells (EAC) cell line in vitro and in vivo. Materials and Methods: Helix collected th...