Actinic keratosis (AK) is a common skin condition caused by long-term sun exposure that has the potential to progress to non-melanoma skin cancers. The objective of this review is to examine the therapeutic options and management of AK globally, particularly in Australia, Canada, and the United Kingdom. Despite its potentially malignant nature, general awareness of AK is low, both in the genera...

Separately, actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC) have been associated with cutaneous human papillomavirus (HPV) infections. To further explore the association between HPV infection and SCC development, we determined markers of cutaneous HPV infection within a single population in persons with precursor lesions (AK), cancerous lesions (SCC), and without. Serum and p...

Let (W, C) be an m-cycle system of order n and let Ω ⊂ W , |Ω| = v < n. We say that a handcuffed design (Ω,P) of order v and block size s (2 ≤ s ≤ m−1) is contained in (W, C) if for every p ∈ P there is an m-cycle c = (a1, a2, . . . , am) ∈ C such that: (1) p = [ak, ak+1, . . . , ak+s−1] for some k ∈ {1, 2, . . . ,m} (i.e. the (s− 1)-path p occurs in the m-cycle c); and (2) ak−1, ak+s ∈ Ω. Note...

Let A be a finite multiset of integers. A second multiset of integers T is said to be an A-tiling of level d if every integer can be expressed in exactly d ways as the sum of an element of A and of an element of T . The set T is indecomposable if it cannot be written as the disjoint union of two proper subsets that are also A-tilings. In this paper we show how to construct indecomposable tiling...

OBJECTIVE Mouse models possessing green fluorescent protein (GFP) and/or human aldose reductase (hAR) in vascular tissues have been established and crossed with naturally diabetic Akita mice to produce new diabetic mouse models. RESEARCH DESIGN AND METHODS Colonies of transgenic C57BL mice expressing GFP (SMAA-GFP), hAR (SMAA-hAR) or both (SMAA-GFP-hAR) in vascular tissues expressing smooth m...

This study was performed to examine the feeding effects of Angelica keiskei Koidz (AK) and its processed products on serum, liver, and body fat content and the expression of antioxidant genes in rats fed a high fat diet. AK and its processed products were added at 3-5% to a high fat diet and fed to adult rats for 6 weeks. In experiment 1 (EXP 1), the rats were fed with one of six diets includin...

Let V be the C∗-algebra B(H) of bounded linear operators acting on the Hilbert space H, or the Jordan algebra S(H) of self-adjoint operators in B(H). For a fixed sequence (i1, . . . , im) with i1, . . . , im ∈ {1, . . . , k}, define a product of A1, . . . , Ak ∈ V by A1 ∗ · · · ∗ Ak = Ai1 . . . Aim . This includes the usual product A1 ∗ · · · ∗ Ak = A1 · · ·Ak and the Jordan triple product A ∗ ...

PURPOSE To develop a nomogram for femtosecond laser astigmatic keratotomy (AK) to treat post-keratoplasty astigmatism. SETTING Three academic medical centers. DESIGN Retrospective interventional case series. METHODS A review of post-keratoplasty femtosecond laser AK was performed. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, manifest refraction, and keratometry were r...

Adenylate kinase (AK) from Escherichia coli was used as both solubility and affinity tag for recombinant protein production. When fused to the N-terminus of a target protein, an AK fusion protein could be expressed in soluble form and purified to near homogeneity in a single step from Blue-Sepherose via affinity elution with micromolar concentration of P1, P5- di (adenosine-5') pentaphosphate (...

Aspartate kinase (AK) is the key enzyme in the biosynthesis of aspartate-derived amino acids. Recombinant AK was efficiently purified and systematically characterized through analysis under optimal conditions combined with steady-state kinetics study. Homogeneous AK was predicted as a decamer with a molecular weight of ~48 kDa and a half-life of 4.5 h. The enzymatic activity was enhanced by eth...