Abstract Carbamazepine (CBZ) is the first-line anticonvulsant drug with a narrow therapeutic index (NTI) and substrate for CYP3A4 MRP-2. Ajuga bracteosa (AB), family Lamiaceae widely used to treat epilepsy, gastric diseases, protects against liver damage in folk. It contains bioactive metabolites, which are powerful inhibitors of CYP3A4, CYP3A5, CYP19, CYP2C19 enzymes P-gp transporter. Concomit...