An efficient approach is presented for performing efficient molecular dynamics simulations of solute aggregation in crystalline solids. The method dynamically divides the total simulation space into "active" regions centered about each minority species, in which regular molecular dynamics is performed. The number, size, and shape of these regions is updated periodically based on the distributio...

An overarching mathematical framework is proposed to describe entire mineral particle precipitation processes including multiple polymorphic forms and ranges of temperatures. While existing models portray individual physical phenomena, the presented approach incorporates a diverse set of the physical phenomena simultaneously within a single mathematical description. The liquid and solid phase d...

b) It was shown that the prepared derivatives distinctly put a stop to the postgerminal development of spores and the vegetative growth of Bacillus cereus 8. Chemical investigation, as well as biological testing of the prepared derivatives is continued. It can be assumed that the easy method of preparation described here will also be useful in the case of other basic peptides possessing antibio...

Morphogenesis (the development of organic form) requires signal-trafficking and cross-talking across all levels of organization to coordinate the operation of metabolic and genomic networked systems. Many biologists are currently converging on the pictorial conventions of computer scientists to render biological signaling as logic circuits supervising the operation of one or more signal-activat...

Formation, aggregation and transmission of abnormal proteins are common features in neurodegenerative disorders including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. The mechanisms underlying protein alterations in neurodegenerative diseases remain controversial. Novel findings highlighted altered protein clearing systems as common biochemi...

In a simplified approach to the in vivo situation, where pathogenic fibrillar protein deposits are often found associated with cellular membranes, the aggregation kinetics of insulin in the presence of various model biomembranes were investigated using the Thioflavin T (ThT) fluorescence assay. The lipid dynamics near the gel-fluid transition, the chain length of saturated lipids and the presen...

Irreversible aggregation processes underly many natural phenomena including, e. g., polymerization [1], gelation [2], island growth [3-4] and aerosols [5]. The classical rate theory of Smoluchowski describes the kinetics of such processes [6-9]. Recently, scaling [10-16] and exact [17-23] theoretical studies showed that spatial correlations play a crucial role in low dimensions. While the above...

Platelet aggregation inhibitory effect and anticoagulant properties of fractions separated from the venoms of Cerastes persicus fieldi and Echis carinatus were investigated. The partial fractionation was performed on a Sephadex G-100 column. Two fractions separated from Cerastes persicus fieldi showed anti platelet aggregation activity on ADP (200 µM)-induced platelet aggregation (ca 80% inhibi...