BACKGROUND Determination of drug safety and tolerability is usually based on the frequency of certain key adverse events (AEs) rather than the frequency of all-grade toxicities. We assessed the reporting of key AEs in oncology randomized, controlled trials (RCTs) and compared that with the expectations of the European Organization for Research and Treatment of Cancer (EORTC) membership. MATER...

There are various methods to collect adverse events (AEs) in clinical trials. The methods how AEs are collected in vaccine trials is of special interest: solicited reporting can lead to over-reporting events that have little or no biological relationship to the vaccine. We assessed the rate of AEs listed in the package insert for the virosomal hepatitis A vaccine Epaxal(®), comparing data colle...

* ايجولونكت دهعم – دادغب , ينقتلا ميلعتلا ةئيه / دادغب ** مسق ةسدنه نداعملاو جاتنلاا , ةيجولونكتلا ةعماجلا / دادغب *** ايجولونكتلاو مولعلا ةرازو / دادغب 497 مييقت لكآتلا ةمواقم طاسوا يف ةيتيركنوكلا ةناسرخلا ةيوقت يف مدختسملا ديدحلل ةفلتخم ةيئام بوقعي فسوي ثيل * شابك ةرهزلا دبع لحز ** و حلاص دمحم قفوم *** 2010/12/21 خیرات میدقتلا : 2011/6/2 خیرات لوبقلا : ةصلاخلا ف حيلستلا ديدحل ...

In this paper an efficient hardware architecture design and implementation of all candidates of AES encryption standards AES-128, AES-192 and AES-256 on the same hardware is proposed. AES algorithm proposed by NIST has been widely accepted as best cryptosystem for wireless communication security. The hardware implementation is useful in wireless security like military and mobile phones. This co...

الگوریتم رمزنگاری aes یکی از متداول ترین الگوریتم های رمزنگاری متقارن است. به علت قابلیت های این الگوریتم، آن را می توان بر روی بسترهای مختلفی ازجمله بـر روی بسـترهای سخـت افزاری نظیر fpga پیاده سازی کرد. همچنین به علت ساختار الگوریتم می توان مسیر داده را به صورت چرخشی و یا غیر چرخشی پیاده سازی نمود. ازآنجاکه بسته به کاربرد، استفاده از هریک از این دو معماری تأثیر فراوانی بر میزان گذردهی و میزان...

OBJECTIVES Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are antipyretic analgesics with established adverse effects (AEs); however, only a few studies have compared their AEs simultaneously. We aimed to compare the AEs of these medications to confirm the respective frequencies of both rare and major AEs. METHODS We used a high-quality database for spontaneous adverse drug e...

BACKGROUND To investigate the average and extrapolated excess length of stay and direct costs of adverse events (AEs) and preventable AEs in Dutch hospitals, and to evaluate patient characteristics associated with excess length of stay and costs. METHODS Data of a large retrospective patient record review study on AEs was used. A stratified sample of 20 Dutch hospitals was included. Excess le...