Nanopore technique has been developed as a powerful approach for single-molecule detection. Current nanopore data analysis method mainly involves time-domian process including the amplitude, translocation duration and interval time of current events. However, more abundant information hidden from noise which lacks quantitative to extract them appropriately. In view advantages that there are int...

Aerolysins initially characterized as virulence factors in bacteria are increasingly found massive genome and transcriptome sequencing data from metazoans. Horizontal gene transfer has been demonstrated the main way of aerolysin-related toxins acquisition However, only few studies have focused on their potential biological functions such organisms. Herein, we present an extensive characterizati...

Abstract Because most of animal viruses are enveloped, cytoplasmic entry these via fusion with cellular membrane initiates their invasion. However, the strategies in which host cells counteract such incompletely understood. Pore-forming toxin aerolysin-like proteins (ALPs) exist throughout kingdom, but functions mostly unknown. In this study, we report that βγ-crystallin fused protein and trefo...