Sir,—Even though some small changes in heart rate were shown to be statistically significant, no clinical significance was attached to such changes. The study was primarily done to assess the overall need of anticholinergic premedication in patients undergoing minor surgery and as such drugs were not administered on a weight basis. However, Dr Gilmour's comment has aroused our interest in this ...

Drug eruptions are probably the most frequent of all manifestations of drug sensitivity. They occur in about 2% of treatment courses and are commoner in women, the elderly and in patients with the acquired immunodeficiency syndrome (AIDS), especially from sulphonamides such as in co-trimoxazole1. Drugs most often incriminated are listed in Table 1. The prevalence of a history of penicillin alle...

The first published report of an adverse reaction to a food additive was that provided by Lockey (1959). He described urticaria in a patient who was given steroid therapy, the formulation of which contained tartrazine. In 1973 the Ministry of Agriculture, Fisheries and Food’s Food Additives and Contaminants Committee produced an interim report on the Review of the Colouring Matter in Food Regul...

Toxicology has two main goals in relation to adverse drug reactions (ADRs). The first is to identify and characterize the potential for harmful effects that can be produced in biological systems, particularly laboratory animals, by a drug, and to suggest therapeutic circumstances in which toxic responses may occur and/or are unlikely to occur. The second is necessary when unexpected adverse cli...

Lenalidomide is an immunomodulatory drug (IMiD) used principally in the treatment of multiple myeloma (MM), myelodysplastic syndromes (MS) and amyloidosis. Adverse reactions related to lenalidomide include myelosuppression (mainly neutropenia but also thrombocytopenia), gastrointestinal problems, skin eruption, atrial fibrillation and asthenia, decreased peripheral blood stem cell yield during ...

The present study emphasizes on implementation of the adverse drug reaction reporting and monitoring system, in the Dermatology department of Kasturba Hospital, Manipal, by a clinical pharmacist, using different promotional activities. Documented adverse drug reactions were assessed and analyzed for incidence, purpose of visit, types, drug classes, individual drug causing adverse drug reactions...