Adverse drug reactions (ADRs) present a serious public health problem that can affect patients, caregivers, pharmaceutical companies, and the health care system as a whole. The objective of the present study was to evaluate Adverse Drug Reactions associated with antihypertensive drugs. The present study was an open, non-comparative, observational study was done to monitor ADRs associated with a...

BACKGROUND The low notification of Adverse Drug Reactions (ADR) underscores the need for pharmacological surveillance systems that allow their detection, evaluation, prevention and registry especially in patients receiving multiple medications. AIM To communicate the ADR observed with the use E coli asparaginase (E coli ASP) in children with Acute Lymphatic Leukemia (ALL). PATIENTS AND METH...

PURPOSE The goal of this study was to characterise adverse drug events (ADE), including both adverse drug reaction (ADR) and accidental poisoning by drugs (AP), considering age, gender, length of stay (LOS), number of deaths and year, during the period 2004-2013. Additionally distributions of the ten's most frequent ADR and AP were characterized, considering age-group and gender. METHODS A re...

<p>Traditional word embedding models have been used in the feature extraction process of deep learning for sentiment analysis. However, these ignore properties words while maintaining contextual relationships and inadequate representation domainspecific words. This paper proposes a method to develop meta model by exploiting domain polarity adverse drug reaction (ADR) features render more ...

BACKGROUND Tuberculosis (TB) is one of the most dangerous infectious diseases and has one of the highest mortality rates. For decades a strong association has been evident between certain socio-economic factors and TB adverse events and failure of treatment, yet there is a limited quantity of literature available on this subject, especially in the Polish literature. MATERIAL AND METHODS We ex...

Background Nonsteroidal antiinflammatory drugs (NSAIDs) and antibiotics are widely used drugs and are the leading causes of adverse drug reaction (ADR), especially skin reactions. The photosensitizing effects of piroxicam are known for a long time and triggered by a photoproduct structurally similar to antigenic thiosalicylic acid present in the chemical formula of thimerosal and piroxicam. The...

PURPOSE To investigate the relationship between different types of adverse drug reaction (ADR) and late time to N-acetylcysteine (NAC) infusion in patients presenting to the hospital with acetaminophen overdose. METHODS This is a retrospective study of patients admitted to the hospital for acute acetaminophen overdose over a period of 5 years (1 January 2004 to 31 December 2008). The primary ...

Background: Patient care services provided by clinical pharmacists should be evaluated periodically to ensure the quality of service. Objectives: This study was conducted to evaluate impact of standard operating procedures (SOPs) on quality of adverse drug reaction (ADR) reporting. Methods: The study was conducted by department of clinical pharmacy located at tertiary care teaching hospital. Qu...

A major challenge to physicians administering drugs with a low therapeutic index, such as chemotherapeutic agents, is the variability in drug disposition and clearance. This variability accounts for the wide interpatient response to conventional doses of antineoplastic agents. Currently, most dosing regimens are based on body weight or surface area, with the decision for dose modifications typi...

OBJECTIVE To compare consistency of adverse drug reaction (ADR) data in publicly available product information documents for brand drugs, between the USA and Europe. To assess the usefulness of information for prescribers and patients. DESIGN A comparison review of product information documents for antidepressants and anticonvulsants concurrently marketed by the same pharmaceutical company in...