Severe adverse drug reactions are an important cause of childhood morbidity and mortality. Despite this, few reports in the literature describe it. This study was designed to evaluate the admitted pediatric patients due to adverse drug reactions. This retrospective study was conducted at Pediatric ward of Besat Hospital. The records of hospitalized patients that admitted with diagnosis of adver...

diphenhydramine, as an antihistamine drug is widely used for the treatment of allergies. however, being classified as an over the counter medication and the general belief on the low adverse effect profile of this drug has made it widely accessible to the families. recent reports of diphenhydramine intoxication and mortality, noticeably in children and infants have raised some serious concerns....

Critically ill patients generally are older, frequently have organ failure, and commonly receive multiple medications, all of which make them susceptible to adverse effects of drugs. Drug interactions are a common adverse effect, and many are predictable based on understanding the mechanisms that underlie drug interactions. This article identifies commonly used medications in critically ill pat...

Early identification of adverse effect of preclinical and commercial drugs is crucial in developing highly efficient therapeutics, since unexpected adverse drug effects account for one-third of all drug failures in drug development. To correlate protein-drug interactions at the molecule level with their clinical outcomes at the organism level, we have developed an integrated approach to studyin...

In pharmacology, it is essential to identify the molecular mechanisms of drug action in order to understand adverse side effects. These adverse side effects have been used to infer whether two drugs share a target protein. However, side-effect similarity of drugs could also be caused by their target proteins being close in a molecular network, which as such could cause similar downstream effect...

Introduction: Amodiaquine is a partner drug in the artemisinin-based combination therapy artesunate-amodiaquine. Reports of the adverse drug reaction known as amodiaquine-associated asthenia are scarce, and this adverse reaction needs to be investigated in detail. This article presents and reviews a case of amodiaquine-associated asthenia. A literature search for the characteri...

BACKGROUND Adverse Drug Reactions are one of the leading causes of injury or death among patients undergoing medical treatments. Not all Adverse Drug Reactions are identified before a drug is made available in the market. Current post-marketing drug surveillance methods, which are based purely on voluntary spontaneous reports, are unable to provide the early indications necessary to prevent the...

background febrile seizure is one of the most prevalent pediatric diseases. an essential part of the physicians’ efforts is to decreasing the parents’ stress level when they confront febrile diseases in children. objectives this study was performed to compare the effects of acetaminophen and ibuprofen on controlling fever and preventing seizures in children with febrile seizure. patients and me...

On social media platforms, users posted fluorescence nails in COVID-19 patients [1]. Web-based news also reported that this finding is linked to the possibility of a side effect. Drug safety information can gather data for pharmacovigilance, science and activities relating detection, assessment, understanding prevention adverse effects or any other drug-related problem [2].