Background: Colorectal cancer is the third commonest worldwide. Most cases presented with locally advanced stage.

Epithelial ovarian cancer is the second most common malignancy of female genital tract, with approximately 7,400 new cases annually in Germany. With 5,500 deaths per year, leading gynecologic cause death. characterized by morphologic heterogeneity 4 molecular biological subtypes (immunoreactive-like, differentiated-like, proliferative-like, mesenchymal-like) different prognosis. Significantly i...

Background and Aims: Chemotherapy is utilized as a part of combined-modality programs to achieve organ preservation and improve survival in patients with locally advanced head and neck cancer. Combinedmodality protocols can be used in three forms: a) neoadjuvant induction chemotherapy before definitive surgery or radiotherapy; b) concomitant chemoradiotherapy; and c) sequential therapy consisti...