PURPOSE We documented the uncoupling of sympathetic nervous system activity from the hypothalamic-pituitary-adrenal axis in cats with feline interstitial cystitis (FIC). Altered hypothalamic-pituitary-adrenal activity was recently suggested in some humans with interstitial cystitis (IC) but to our knowledge no information exists on adrenal gland size and histopathology in this disease. To inves...

Adult mouse mutants homozygous for an engineered proopiomelanocortin (POMC)-null allele lack macroscopically distinct adrenal glands and circulating adrenal hormones. To understand the basis for this adrenal defect, we compared the development of adrenal primordia in POMC-null mice and littermate controls. POMC-null mutant mice are born with adrenal glands that are morphologically indistinguish...

Abstract. Modern technological conditions of keeping and exploitation animals poultry do not exclude the negative impact stress on their body. This leads to a decrease in body’s resistance, an increase morbidity mortality. In addition, quantity quality products obtained are reduced. Stress prevention helps natural resistance The search for effective means preventing reactions body animal husban...

We report a case history of an 84-year-old elderly male patient that presented with a clinical picture suggestive of adrenal failure and bilateral adrenal nodules detected by abdominal computed tomography. A fine needle-guided biopsy was inconclusive for achieving a final diagnosis. The patient died due to septic shock and the autopsy disclosed histoplasmosis with extensive bilateral necrosis o...

OCT4 immunostaining has become an essential resource in diagnosing germ cell neoplasia. OCT4 is a transcription factor with a characteristic nuclear staining pattern specific to germ cell neoplasms. Our institution has observed that paraganglionic tissue consistently displayed intense cytoplasmic staining by utilizing monoclonal OCT4 antibody, and we intended to determine whether OCT4 could pro...

It has been shown earlier (1) that the metabolism of carbohydrate is disturbed in scorbutic guinea pigs as evidenced by diminished glucose tolerance, deposition of liver glycogen, and insulin content of the pancreas. Although the adrenalin content of the adrenals of scorbutic guinea pigs is increased, it has been shown by removing the adrenal medulla that adrenalin is not responsible for the lo...