After heart disease, cancer continues to be the second most prevalent cause of death in USA. Several chemotherapeutic treatments (drugs) are available for that use powerful chemicals kill body's rapidly proliferating cells. However, recent research disclosed many clinically viable anticancer drugs have been developed with help originating from plants. A number phytochemicals isolated plants pos...

Objective: Furin is the family of proprotein convertase and localized in Trans Golgi Network (TGN) and cell surface. It is the major processing enzyme of the secretory pathway. Furin inhibitors are known to be therapeutic agents since it is involved in viral and bacterial activation, alzimer’s disease and cancer. Furin is the family of proprotein convertase and localized in Trans Golgi Network ...

Objective: Proprotein convertase subtilisin kexin 9 (PCSK9) has medical significance in lowering cholesterol levels. Inhibitors target and inactivate PCSK9 in the liver. Knocking out PCSK9 reduces the amount of harmful low-density lipoprotein cholesterol (LDL-C) circulating in the bloodstream. There are two known inhibitors for treating the cardiovascular disease “Arilocumab” and “Evalocumab.” ...

We study germs of smooth vector fields in a neighborhood of a fixed point having an hyperbolic linear part at this point. It is well known that the “small divisors” are invisible either for the smooth linearization or normal form problem. We prove that this is completely different in the smooth Gevrey category. We prove that a germ of smooth α-Gevrey vector field with an hyperbolic linear part ...

Modern drug testing and design includes experimental in vivo and in vitro measurements, combined with in silico computations that enable prediction of the drug candidate’s ADMET (adsorption, distribution, metabolism, elimination and toxicity) properties in the early stages of drug discovery. Recent estimates place the discovery and development cost of a small drug molecule close to US $1.3 bill...