PURPOSE To investigate the impact of chemotherapy and/or radiotherapy on disease-free survival (DFS) and overall survival (OS) rates of patients with thymic carcinoma after complete resection. METHODS Between 2001 and 2013, 54 patients with complete resection of thymic carcinoma in Hangzhou Cancer Hospital were retrospectively reviewed. The Kaplan-Meier method was used to evaluate the surviva...

Background: Low-grade astrocytomas are the most common pediatric central nervous system tumours. They can occur anywhere in the central nervous system and are often challenging to treat. Methods: A retrospective review to compare the response to therapy for spinal cord astrocytomas to that of brain astrocytomas. Results: Five patients had low-grade spinal cord astrocytoma and 43 had low-grade b...

Breast cancer is the most common malignant tumor affecting women. Adjuvant systemic therapies have been shown to have a significant impact on reducing the risk for breast cancer recurrence and overall mortality. Chemotherapy remains an important and frequently used treatment option in the adjuvant setting, and the associated short-term adverse events are very well described. However, there is i...

Endometrial cancer generally has a good prognosis because most cases are diagnosed in stage I. It is possible to identify subgroups of patients with early-stage endometrial cancer with a poor prognosis. Despite a traditional generous use of adjuvant radiotherapy, these patients have five-year overall survival of approximately 80%. In this group there is a need for an effective systemic adjuvant...

BACKGROUND AND PURPOSE Neo-adjuvant chemotherapy is recommended for 'inoperable' locally advanced and inflammatory breast cancers. For operable breast cancers, trials indicate no survival differences between chemotherapy given pre or post-surgery. Communicating evidence based information to patients is complex and studies examining patient experiences of neo-adjuvant chemotherapy are lacking. T...

BACKGROUND Adjuvant chemotherapy after the resection of stage IB-IIIA non-small cell lung cancer (NSCLC) is now the standard of care based on large-scale phase III trials and a meta-analysis. However, chemotherapy has plateaued in terms of its efficacy, and the search for treatment prediction biomarkers is imperative for the further identification of treatable subgroups. Therefore, we investiga...

o determine the optimal use of chemotherapy in the neoadjuvant, adjuvant, and metastatic setting in patients with dvanced urothelial cell carcinoma, a consensus conference was convened by the World Health Organization (WHO) nd the Société Internationale d’Urologie (SIU) to critically review the published literature on chemotherapy for atients with locally advanced bladder cancer. This article r...