Background: Application of haptens to the skin induces release immune stimulatory adenosine triphosphate into extracellular space. This “danger” signal can be converted immunosuppressive by action ectonucleotidases CD39 and CD73, expressed cells. CD73 deficient mice have thicker ear swelling 1 day after challenge. On other hand, neutrophil is also essential induce contact hypersensitivity(CHS) ...

The properties of the glucose 6-phosphate-dependent forms of glycogen synthetase obtained by incubation with calcium ions or with adenosine triphosphate were compared. The two preparations showed different sensitivity to the action of heat and trypsin. In addition, the synthetase obtained with adenosine triphosphate is reconvertible to the independent form while that prepared with Ca++ is not. ...

Our previous reports have presented evidence suggesting the existence in tumor cells of a second control site of glycolysis of pyruvate kinase as a competition for adenosine diphosphate between this enzyme and mitochondria, which is responsible for the Crabtree effect. Now, by using cells partially permeabilized to nucleotides and phosphorylated substrates, we provide evidence supporting the ex...

We have used in vivo 31P-nuclear magnetic resonance spectroscopy to study the changes in high-energy phosphates following hyperthermia. Immediately after heating, there is a fall in adenosine triphosphate and apparent intracellular pH and an increase in inorganic phosphate. Following sublethal heating (40 degrees for 15 min), these changes were partial, and they resolved over the subsequent 45 ...

Aims Coronary heart disease is one of the leading causes of mortality in modern societies. The disease is associated with the lack of physical activity and the expression of some genes involved in blood cholesterol transportation. Adenosine triphosphate (ATP)-binding cassette transporters G5/G8) ABCG5 and ABCG8) is the expression of adenosine triphosphate-dependent box protein genes 5 and 8, a ...

A 40-fold purification of adenosine diphosphoglucose pyrophosphorylase from sweet corn (Zea mays var. Golden Beauty) revealed the enzyme to be specific for adenosine triphosphate. The enzyme has an absolute requirement for Mg(2+) and is activated by 3-phosphoglycerate and to a lesser extent by ribose-5-phosphate and fructose-6-phosphate. The apparent Km values of the enzyme for glucose-1-phosph...

PURPOSE OF REVIEW To review the profile of ETC-1002, as shown in preclinical and clinical studies, including LDL-cholesterol (LDL-C)-lowering activity and beneficial effects on other cardiometabolic risk markers as they relate to the inhibition of adenosine triphosphate-citrate lyase and the activation of adenosine monophosphate-activated protein kinase. RECENT FINDINGS ETC-1002 is an adenosi...