COX-2 is upregulated in most colorectal cancers. Most of the COX-2 tumor-inducing effects are believed to be mediated through overproduction of prostaglandin E(2) (PGE(2)), which can be measured using a urinary metabolite of PGE(2), PGE-M. Urinary PGE-M was assessed in a case-control study of colorectal adenoma. Included in the analysis were 224 cases with at least one advanced adenoma, 152 cas...

BACKGROUND/AIMS The efficacy and safety of endoscopic resection of colorectal cancer derived from sessile serrated adenomas or traditional serrated adenomas are still unknown. The aims of this study were to verify the characteristics and outcomes of endoscopically resected early colorectal cancers developed from serrated polyps. METHODS Among patients who received endoscopic resection of earl...

Most of colorectal adenocarcinomas are believed to arise from adenomas, which are premalignant lesions. Sequencing the whole exome of the adenoma will help identifying molecular biomarkers that can predict the occurrence of adenocarcinoma more precisely and help understanding the molecular pathways underlying the initial stage of colorectal tumorigenesis. We performed the exome capture sequenci...

OBJECTIVE There are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma genome atlas and identify molecular markers of progression from colorectal adenoma to adenocarcinoma. DESIGN Whole-exome sequencing and targeted sequencing were carried out in 149 adenoma samples and paired blood from patients wi...

Previous studies have shown that CCNB1 affects the invasiveness of pituitary adenomas, and it is great significance to find upstream mechanism regulating CCNB1.In this study, we explored a significantly overexpressed circRNA in invasive adenomas. Based on bioinformatics analysis experiments, determined circNFIX (has-circ_0005660) cell invasion, migration proliferation adenomas by sponging miR-3...

benign renal cystic adenoma with out malignant features is a very rare entity. a 75 year old male with obstructive lower tract symptoms and vague flank pain was admitted and planned for nephrectomy of non functional kidney -due to long term nephrolithiasis- intra operative finding was a cystic hydronephrotic kidney filled by thick mucous secretions which turned out to be a cyst adenoma of kidne...

Salivary gland-type adenoma, especially monomorphic adenoma in the lung is very rare. We report a 66-year-old previously healthy woman who developed cough, hemosputum, and fever. Bronchoscopy revealed an endobronchial mass in the proximal portion of the left lower lobe bronchus. Following left lower lobectomy, the pathological diagnosis was an unusual monomorphic adenoma of the salivary gland-t...

Pleomorphic adenoma is a benign tumor of the salivary glands, most commonly affecting the parotid gland. Pleomorphic adenoma of the ear is rare. The use of imaging modalities, especially magnetic resonance imaging (MRI), is particularly useful in localizing and surgical planning of these tumors. We present a case of pleomorphic adenoma invading the mastoid cortical bone, with review of literature.

Nephrogenic adenoma is a rare, benign lesion of the urinary tract, which can mimic malignant tumour.1 Until now, less than 30 cases of nephrogenic adenoma of the ureter have been reported, and its aetiological factors have not been systematically described. Here, we describe a case of ureteral nephrogenic adenoma associated with chronic recreational ketamine abuse, which we suspected to be an a...

Pleomorphic adenoma is the most common benign salivary gland tumour. It can occur in any salivary gland, but is most frequently found in the parotid gland. Chondroid metaplasia is a frequent finding in pleomorphic adenoma. Other forms of metaplasia have been described, but are encountered less frequently. We report a rare case of unusual pleomorphic adenoma of the parotid gland with schwannoma-...