© 2008 Association médicale canadienne A cystic carcinomas (ACCs) constitute 0.1%–1% of all malignant breast tumours. They have better prognosis than other breast masses: they usually do not metastasize, and treatment is usually followed by prolonged survival. We present a case of multifocal, focally infiltrating ACC of the breast. A search of the English literature failed to reveal any other s...

BACKGROUND Laryngeal adenoid cystic carcinoma (ACC) is a rare disease. We reviewed our experience at the Princess Margaret Hospital (PMH) with its treatment. METHODS This is a retrospective chart review of 15 cases treated at PMH between 1963 and 2005. RESULTS The mean age was 48.6 years. There was no sex predilection. The subglottis was the most common subsite involved. Only 2 patients had...

UNLABELLED A 65 year-old male patient with a one year-duration tumoral growth located in the upper lip was diagnosed on incisional biopsy as epithelial-myoepithelial carcinoma. After wide surgical excision the histopathological analysis revealed the lesion was composed predominantly (>90%) of adenoid cystic carcinoma. In new sections it was found a very small and isolated area of adenoid cystic...

Adenoid cystic carcinoma, or cylindroma, usually presents in the salivary glands or in the upper respiratory passages. We report an unusual case of adenoid cystic carcinoma in a 45-year-old woman who presented with a three-year history of progressive right trigeminal sensory palsy, most pronounced in the second division. There was, in addition, a right trigeminal motor palsy and a partial right...

INTRODUCTION Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in the salivary glands. Its occurrence elsewhere is rare and its metastasis to the thyroid gland has been described only once. CASE REPORT We describe the case of a 66-year-old man who presented for a swelling in the midline neck of six months duration. A solitary palpable nodule was identified in the isth...

SMAD4, also known as DPC4 (deleted in pancreatic carcinoma 4) was initially identified as a tumor-suppressor gene. It is located on 18q21, a region frequently deleted in pancreatic carcinoma. Functionally inactivating mutation of the gene also occurs in many cases of pancreatic cancer. Functional loss of SMAD4 is frequently detected not only in pancreatic carcinoma but also in colorectal carcin...

erbB2 gene plays an important role in carcinoma formation. erbB2 overexpression was observed in many types of tumours, including salivary carcinoma. However, a putative erbB2 and PTEN interaction remains largely unknown in salivary adenoid cystic carcinoma cells. The purpose of this study was to silence erbB2 gene and investigate the functional relationship between erbB2 and PTEN in SACC-83 sal...