background: breast cancer is the most common malignancy in women. breast cancer type 1 susceptibility gene (brca1) is a tumor suppressor gene, involved in dna damage repair and in 81% of the breast-ovarian cancer families were due to brca1. in some clinically investigated genes, the intragenic marker polymorphism is important and the screening of such mutations is faster by using short tandem r...

Dear Editor, Leptomeningeal carcinomatosis is a rare, but wellknown form of metastatic breast cancer, seen in up to 6% of breast cancer patients at autopsy (Tsukada et al., 1983). It most often occurs in the setting of a known primary malignancy and may present with signs and symptoms referable to anywhere along the neuroaxis. We report two patients who presented with isolated carcinomatous cau...

the postgastrectomy recurrence rate is as high as 30-65%, with 5-year overall survival rates of <20%. local recurrence is very common which occurs in 38-45% of cases. the most common sites of locoregional recurrence are the gastric remnant at the anastomosis, the gastric bed, and the regional nodes. the recurrence may occur as early and late events after gastrectomy. most recurrences are early,...

most patients with gastrointestinal cancers refer to the health centers at advanced stages of the disease and conventional treatments are not significantly effective for these patients. therefore, using modern therapeutic approaches with lower toxicity bring higher chance for successful treatment and reduced adverse effects in such patients. the aim of this study is to evaluate the effect of av...

Multiple cancers may occur in an individual because of a genetic predisposition, environmental exposure, cancer therapy, or immunological deficiency. We presented two patients with two cancers in the West of Iran. Case 1: a 52-year-old woman referred to Clinic of Oncology (December 2010) with complaints of left breast lump with induration. The pathology report had shown invasive ductal carcinom...

The cytotoxicity of 27 benzanilides and dithiobenzanilides built on a stilbene scaffold and possessing various functional groups in aromatic rings previously described for their spasmolytic properties was assayed on three human cancer cell lines (A549 -lung adenocarcinoma, MCF-7 estrogen dependent breast adenocarcinoma and MDA-MB-231 estrogen independent breast adenocarcinoma) and 2 non-tumorig...

background: breast cancer incidence has increased rapidly inkuwait, but there haven’t been any studies investigating the recognized risk factors of breast cancer inkuwait. the aim of the study was to investigate breast cancer risk factors among women inkuwait.   methods: a case-control study was conducted in kuwait from may 2003 to march 2004 using a questionnaire including socio-demographic da...

• Breast adenocarcinoma- brain endothelial de-adhesion dynamics is presented. Adenocarcinoma-derived exosomes alter pattern of endothelium. Intercellular mechanics might play important role in metastatic niche formation. Despite advances modern therapeutics, one the most feared complications cancer are metastases, which often cause life impairing profound neurological symptoms and premature dea...

Gastrointestinal metastasis of the breast cancer is rare and its management varies significantly from that of a primary bowel cancer. We report a case of invasive ductal cancer metastasizing to the rectum and masquerading as a rectal primary. A 60 year old caucasian woman presented with fresh rectal bleeding nine years after treatment of her primary breast cancer. The investigations revealed fe...