Risky drinking behaviour can strongly influence the lives of individuals and families, including having negative effects on social welfare and health. The low rate of healthcare service use among people experiencing alcohol addiction is an important problem in Thai society. The overall aim of the study was to explore the barriers to alcohol treatments for people experiencing alcohol addiction. ...

Abuse of psychoactive substances can lead to drug addiction. In animals, addiction is best modeled by drug self-administration paradigms. It has been proposed that the crucial common denominator for the development of drug addiction is the ability of drugs of abuse to increase extracellular concentrations of dopamine in the nucleus accumbens (NAcc). Studies using in vivo microdialysis and chron...

brated the 30th anniversary of the Center for Alcohol and Addiction Studies with a daylong colloquium on Sept. 21. Keynote speaker DAVID ABRAMS came to Brown in the late 1970s as a clinical psychology intern interested in behavior therapy treatment of tobacco and alcohol addiction. Here he found a stalwart cadre of empathetic academics and clinicians who didn’t see addiction as a question of im...

CONTEXT Understanding the mechanisms underlying nicotine addiction to develop more effective treatment is a public health priority. Research consistently shows that nicotine transiently improves multiple cognitive functions. However, using nicotine replacement to treat nicotine addiction yields generally inconsistent results. Although this dichotomy is well known, the reasons are unclear. Imagi...

Addiction represents a complex interaction between the reward and stress neural circuits, with increasing drug use reflecting a shift from positive reinforcement to negative reinforcement mechanisms in sustaining drug dependence. Preclinical studies have indicated the involvement of regions within the extended amygdala as subserving this transition, especially under stressful conditions. In the...

DESIGN This is a structured evidence-based review of all available studies on the development of abuse/addiction and aberrant drug-related behaviors (ADRBs) in chronic pain patients (CPPs) with nonmalignant pain on exposure to chronic opioid analgesic therapy (COAT). OBJECTIVES To determine what percentage of CPPs develop abuse/addiction and/or ADRBs on COAT exposure. METHOD Computer and ma...

Electrostimulation is now a relatively sophisticated technique with broad applications in medicine and psychiatry. It has been used for over 30 years in the addiction field, and is widely used internationally for this indication especially in America. It is also used for sleep problems, anxiety, depression, and cognitive dysfunction as well as for pain and other physical conditions, many of whi...

BACKGROUND Internet addiction can seriously affect the social functioning and studies of college students in China but measures for addressing this problem have not yet been developed or tested. OBJECTIVE Assess the personality characteristics of college students with internet addiction. METHODS Two self-report scales, the Tridimensional Personality Questionnaire (TPQ) and the Chen Internet...

Development of new treatments for drug addiction will depend on high-throughput screening in animal models. However, an addiction biomarker fit for rapid testing, and useful in both humans and animals, is not currently available. Economic models are promising candidates. They offer a structured quantitative approach to modeling behavior that is mathematically identical across species, and accru...

Our previous study revealed that aquaporin 4 (AQP4) knockout attenuated locomotor activity in cocaine exposure mice and reduced the extracellular dopamine levels in the nucleus accumbens, suggesting that AQP4 might participate in cocaine addiction. The aim of the present study was to investigate the impact of AQP4 on cell proliferation of dentate gyrus in the mouse hippocampus after repeated co...