Climate is one of the most important drivers of local adaptation in forest tree species. Standing levels of genetic diversity and structure within and among natural populations of forest trees are determined by the interplay between climatic heterogeneity and the balance between selection and gene flow. To investigate this interplay, single nucleotide polymorphisms (SNPs) were genotyped in 24 t...

Considerable progress has been made in recent years toward elucidating a conceptual framework that integrates the dynamic functional structure, mechanical properties, and pathobiological behavior of the cardiac valves. This communication reviews the evolving paradigm of a continuum of heart valve structure, function, and pathobiology and explores its implications. Specifically, we discuss (1) t...

(Mountain biodiversity in Brazil). The high species richness and diversity found in tropical montane habitats are often related to: 1) an effect of climatic and geological history on biotic evolution; 2) the various environmental impacts on species adaptation mechanisms; and 3) the continuous dispersal of fauna and flora in time. However, little is known about how these factors shaped species r...

Many debilitating neuropsychiatric and neurodegenerative disorders are characterized by dopamine neurotransmitter dysregulation. Monitoring subsecond dopamine release accurately and for extended, clinically relevant timescales is a critical unmet need. Especially valuable has been the development of electrochemical fast-scan cyclic voltammetry implementing microsized carbon fiber probe implants...

Domain adaptation algorithms address a key issue in applied machine learning: How can we train a system under a source distribution but achieve high performance under a different target distribution? We tackle this question for divergent distributions where crucial predictive target features may not even have support under the source distribution. In this setting, the key intuition is that that...

Tribulus terrestris herb has been used as a drug in traditional medicine and its toxic effects have also been reported. Less attention has been paid to the interpretation of pathological and laboratory findings in the natural form poisoning with this plant in animals. Following a report of mortalities in a sheep farm feeding on a pasture containing Tribulus terrestris herb and involvement of 50...