Viral infection imposes a major threat to human health. To develop new potent antiviral agents, Hederagenin (HE), known inhibitor of HIV-1 and HCV NS3/4A proteases, was used as starting material synthesize 4 types HE derivatives, HE-3,23-diacyl, HES-3,23-diacyl, HES-3-acyl, HES-3-oxo-23-acyl. We evaluated the in vitro inhibitory activities derivatives against proteases. (3 β,23)-Di- O-diglutary...

Abstract Novel acyl pyrazoles and triazoles have been prepared by means of the oxidative amidation aldehydes in presence requisite azole. Yields range from modest to good both cases, some limitations substrate scope discovered. Acyl were treatment a mixture aldehyde pyrazole with an oxoammonium salt bearing nitrate anion. In case triazoles, functionalization was performed using sodium persulfat...

Biohybrid systems can combine inorganic light-harvesting materials and whole-cell biocatalysts to utilize solar energy for the production of chemicals fuels. Whole-cell have an intrinsic self-repair ability are able produce a wide variety multicarbon in sustainable way with metabolic engineering. Current biohybrid yet undefined electron transfer pathway between light-absorber enzymes, limiting ...

The reaction of 2,2'-dithio-bis(benzenamine) with furan-2-carbonyl chloride produced the bis-amide title compound, C(22)H(16)N(2)O(4)S(2), which, in the crystal, formed a helix; the structure consists of two planar furanoylbenzenamines related by an improper rotation of 96.3° about the S-S bond. The N-furanoylbenzenamine units are planar (maximum deviations = 0.316 and 0.132 Å). Each electron-d...

Interactions of different anions with phospholipid membranes in aqueous salt solutions were investigated by molecular dynamics simulations and fluorescence solvent relaxation measurements. Both approaches indicate that the anion-membrane interaction increases with the size and softness of the anion. Calculations show that iodide exhibits a genuine affinity for the membrane, which is due to its ...

An alternative and effective route to prepare conducting polyaniline-grafted reduced graphene oxide (PANi-g-rGO) composite with highly enhanced properties is reported. In order to prepare PANi-g-rGO, amine-protected 4-aminophenol was initially grafted to graphite oxide (GO) via acyl chemistry where a concomitant partial reduction of GO occurred due to the refluxing and exposure of GO to thionyl...

A series of 1-acyl-4-phenyl/(acridin-9-yl)thiosemicarbazides 3, including four new compounds, were prepared in order to study substituent effects on cyclization reactions with oxalyl chloride (producing imidazolidine-4,5-diones 4), dimethyl acetylenedicarboxylate (to give thiazolidin-4-ones 7 and 8) and autocondensation under alkaline conditions (to yield 1,2,4-triazoles 9). A positional isomer...

Eighteen N-substituted phenyl-2-acyloxycyclohexylsulfonamides (III) were designed and synthesized by the reaction of N-substituted phenyl-2-hydroxyl- cycloalkylsulfonamides (I, R(1)) with acyl chloride (II, R(2)) in dichloromethane under the catalysis of TMEDA and molecular sieve. High fungicidal active compound N-(2,4,5-trichlorophenyl)-2-(2-ethoxyacetoxy) cyclohexylsulfonamide (III-18) was sc...

At1g78690p, a gene found in Arabidopsis thaliana, has been reported to encode a Nacyltransferase (NAT) that transfers an acyl chain from acyl-CoA to the head-group of phosphatidylethanolamine (PE) to form N-acyl phosphatidylethanolamine (N-acyl PE). Our investigation suggests that At1g78690p is not a PE-dependent NAT, but is instead a lysoglycerophospholipid O-acyltransferase. We over-expressed...